反流性食管炎大鼠模型造模方法简述  

Rat models of reflux esophagitis

作　　者：程正义[1] 张娇[2] 王凤云[3] 唐旭东[3] 李保双[3] 

机构地区：[1]中国中医科学院研究生院,北京市100700 [2]北京中医药大学研究生院,北京市100029 [3]中国中医科学院西苑医院消化科,北京市100091

出　　处：《世界华人消化杂志》2015年第28期4515-4521,共7页World Chinese Journal of Digestology

基　　金：北京市科委科研基金资助项目;No.Z141100002214012~~

摘　　要：胃食管反流病(gastroesophageal reflux disease,GERD)是指胃内容物反流入食管而引起不适症状和/或并发症的一组疾病.GERD是一种临床常见的、容易复发的功能性胃肠病.反流性食管炎(reflux esophagitis,RE)是GERD的一个重要的分型.作为研究GERD病理生理变化以及开发治疗性药物的手段,需要较多的用到实验动物模型.RE因其存在器质性病变,易于通过动物模型研究其发病机制,故而在有关GERD的动物实验报告中占据多数.RE动物模型的制备主要分为两种,一种是急性离体或在体食管灌注试验研究,另一种是慢性实验,通过胃肠道手术建立反流动物模型.RE大鼠模型制备主要包括单纯酸性反流、单纯碱性反流和酸碱混合反流3种术式.Gastroesophageal reflux disease（GERD）refers to the reflux of gastric contents into the esophagus,which causes discomfort symptoms and（or） a group of complications.GERD is a functional gastrointestinal disorder,which is clinically common and easy to recur.Reflux esophagitis（RE） is an important type of GERD.During the study of pathological and physiological changes of GERD and the development of drugs,animal models were used frequently.Due to the existence of organic changes in RE,it is easy to develop animal models of RE to study its pathogenesis,therefore there are more reports of animal models of RE in the study of GERD.Currently,there are two kinds of methods to develop animal models of RE;one is acute esophageal perfusion,and the other is surgical operation to cause the reflux of gastric contents.The surgical procedures to cause reflux of gastric contents into the esophagus in rats were divided into three types,namely,simple acid reflux,pure alkaline reflux and mixed-type reflux.

关 键 词：胃食管反流病 反流性食管炎 大鼠 模型 

分 类 号：R571[医药卫生—消化系统]