普洱熟茶茶褐素对2型糖尿病小鼠降糖作用研究  

Hypoglycemic Effects of Fermented Puer tea Extracts- Theabrownins in Mice of Type 2 Diabetes

作　　者：徐湘婷[1] 王鹏[1] 罗绍忠[1] 侯艳[2] 邵宛芳[2] 杨继红[1] 

机构地区：[1]昆明医科大学药学院暨重点实验室,云南昆明650500 [2]云南农业大学龙润普洱茶学院,云南昆明650201

出　　处：《中国民族民间医药》2015年第20期9-10,共2页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：国家科技支撑计划课题子课题(2007BAD58B04-4);云南省教育厅科学研究基金项目(2012C009)

摘　　要：目的:探讨普洱熟茶提取物茶褐素对2型糖尿病小鼠的降血糖作用及其机制。方法:高脂饮食加低剂量链脲菌素建立小鼠2型糖尿病模型,连续灌胃给予0.25、0.5、1.0g/kg/d茶褐素6周,实验结束后检测空腹血糖、胰岛素、甘油三酯、总胆固醇,取肝脏测肝糖原含量。结果:普洱熟茶茶褐素与模型组比较:空腹血糖、胰岛素、甘油三酯、总胆固醇显著降低,肝糖原显著升高。结论:普洱熟茶提取物茶褐素可有效降低2型糖尿病小鼠的血糖水平及改善其糖、脂代谢,作用机制可能与增加胰岛素敏感性有关。Objective： To ex- plore the hypoglycemic effects and mechanisms of theabrownins from fermented Puer tea in mice of Type 2 diabetes. Methods： To de- velop a mice model of type 2 diabetes mellitus by high fat diet with low dose streptozotocin. At the experimental endpoint, the fasting serum glucose, insulin, triglyeeride, total cholesterol and liver glycogen levels were measured. Results： The comparison among the- abrownins of fermented Puer tea groups and model group revealed that： Levels of the fasting serum glucose, insulin, triglyceride and total cholesterol were decreased and liver glycogen levels increased significantly in theabrownins groups. Conclusion： fermented Puer tea extracts - theabrownins can be used as treatment for the mice model of type 2 diabetes mellitus. Theabrownins can improved glu- cose and lipid metabolism, and this effect may be associated with increasing insulin sensitivity.

关 键 词：茶褐素 糖尿病小鼠 血糖 

分 类 号：R-332[医药卫生]