^(99)Tc^m-MIBI SPECT-CT融合显像在腮腺区良恶性肿瘤鉴别的应用价值  

Application of ^(99)Tc^m- MIBI SPECT-CT for Differential Diagnosis of Benign and Malignant Parotid Tumors

作　　者：刘洪伟[1] 李宁毅[2] 

机构地区：[1]济宁市第一人民医院口腔颌面外科,山东济宁272000 [2]青岛大学医学院附属医院口腔颌面外科,山东青岛266003

出　　处：《口腔医学研究》2015年第10期1017-1019,1023,共4页Journal of Oral Science Research

基　　金：山东省济宁市科技发展计划项目(编号:200956220)

摘　　要：目的:探讨锝(99mTc)甲氧异腈(99mTc-methoxyisobutylisonitrile 99 Tc m-MIBI)SPECT-CT在腮腺肿块术前定性诊断的价值。方法:对30例单侧腮腺肿块患者术前行腮腺区SPECT-CT显像,以99 Tc m-MIBI为显像剂,所有病例均行融合显像判断肿块性质。定性分析行χ2检验、放射性摄取比值(T/N)行t检验。判断结果分别与临床检查、病理诊断相比较。结果:99 Tc m-MIBI SPECT-CT对腮腺区肿块诊断的敏感性、特异性、准确性分别为84.61%、94.12%、90.00%。17例腮腺良性肿块,其中16例阴性(94.11%,16/17),1例显示假阳性(5.89%,1/17)。99 Tc m-MIBI SPECT-CT融合显像13例腮腺恶性肿瘤显示12例阳性(92.31%,12/13),1例淋巴瘤出现假阴性(7.69%)。定性分析经χ2检验有统计学意义。计算腮腺区良恶性肿块放射性摄取比值(T/N)(1.42±0.62),(2.32±0.58),经t检验两者差别有统计学意义(P<0.05)。结论:99 Tc m-MIBI SPECT-CT对鉴别腮腺区良恶性肿块有良好的应用价值。Objective：To evaluate the clinical application of ^99Tc^m-methoxyisobutylis-onitrile（^99Tc^m- MIBI）SPECT-CT for differential diagnosis of benign and malignant parotid tumors before treatment.Methods：SPECTCT fusion images of parotid regions were obtained from 30 patients with unilateral parotid gland tumor before surgery.^99Tc^m-MIBI was used as the imaging agent.The results were compared with their pathological diagnoses and clinical examination.The chi-square test and t-test were used for statistical analysis.Results：The sensitivity,specificity and accuracy of ^99Tc^m-MIBI SPECT-CT fusion imaging in determining the malignant parotid tumors were 84.61%,94.12%and 90.00%,respectively.Sixteen of 17 patients with benign tumors showed negative images（94.11%,16/17）,while 1of 17 patients showed positive images（5.89%,1/17）.In addition,12 of 13patients with malignant tumors showed positive images（92.31%,12/13）,while 1of 13 patients showed negative image（7.69%,1/13）.There were significant differences between two groups by chi-square test.The uptake ratios of benign and malignant parotid tumors were 1.42±0.6and 2.32±0.58（P〈0.05）,respectively.Conclusion：^99Tc^m-MIBI SPECT-CT might be a useful method for differential diagnosis of benign and malignant parotid tumors before treatment.

关 键 词：腮腺肿瘤 放射性同位素 体层摄影术 SPECT-CT 

分 类 号：R739.8[医药卫生—肿瘤]