胆汁反流、幽门螺杆菌感染对Barrett’s食管的影响  

Effect of bile regurgitation and Helicobacter pylori infection for Barrett's esophagus

作　　者：宁丹丹[1] 

机构地区：[1]哈尔滨医科大学附属第二医院消化内科,黑龙江哈尔滨150000

出　　处：《胃肠病学和肝病学杂志》2015年第10期1200-1201,共2页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨Barrett’s食管(Barrett’s esophagus,BE)与幽门螺杆菌(H.pylori)感染、胆汁反流的关系。方法采用胃镜检查结合病理检查结果对30例BE患者进行分析,同时选取健康对照者30名作为对照组,采用快速尿素酶法及Warthin-Starry银染两种方法检测H.pylori感染;应用便携式胆汁监测仪检测食管24 h胆汁反流情况。结果 BE组中,H.pylori感染率为30.00%,胆汁反流患病率为76.67%。对照组中,H.pylori感染率为60.00%,胆汁反流患病率为6.67%。BE组H.pylori的检出率明显低于对照组(P<0.05)。BE组胆汁反流发生率明显高于对照组(P<0.05)。结论 H.pylori对BE可能有保护作用,胆汁反流与BE关系密切。Objective To study the relationship of bile regurgitation,Helicobacter pylori（ H. pylori） infection with Barrett＇s esophagus（ BE）. Methods Thirty BE patients who underwent gastric endoscopy and pathological examination served as the BE group,30 normal subjects served as the control group. H. pylori infection was detected by rapid urease test with Warthin-Starry staining. Bile regurgitation in 24 hours was detected by ambulatory 24 hours bilirubin monitoring technique. Results The H. pylori detection rate was significantly lower in BE group（ 30. 00%） than that in control group（ 60. 00%）（ P〈0. 05）. The incidence of bile regurgitation was significantly higher in BE group（ 76. 67%） than that in control group（ 6. 67%）（ P〈0. 05）. Conclusion H. pylori may protect BE. Bile regurgitation is closely related to BE.

关 键 词：胆汁反流 幽门螺杆菌 Barrett’s食管 

分 类 号：R571[医药卫生—消化系统]