钛种植体表面矿化胶原涂层的生物学性能研究  

Biological property evaluation of the mineralized collagen coatings on titanium implant surface

作　　者：孙鑫[1] 魏军水[1] 徐金标[1] 

机构地区：[1]浙江省台州市第一人民医院口腔科,浙江台州318020

出　　处：《口腔医学》2015年第10期822-825,共4页Stomatology

摘　　要：目的钛种植体表面应用电化学沉积技术制备的矿化胶原涂层的生物学性能研究。方法本研究应用电化学沉积技术在钛金属表面制备了矿化胶原涂层,应用模拟体液(SBF)浸泡表征其诱导羟基磷灰石骨性结合能力,利用MTS法检测涂层的细胞粘附及增殖性能。结果制备的矿化胶原涂层能在SBF中稳定存在并继续矿化,能促进植入成骨前体细胞在其表面的粘附、增殖和分化。结论钛种植体表面进行矿化胶原涂层修饰可以有效促进其生物活性。Objective To study the biological performance of the mineralized collagen coatings on titanium implant prepared by electrochemical deposition technique. Methods In this study,the electrochemical deposition technique was used to prepare the mineralized collagen coating on titanium surface,simulated body fluid（ SBF） was used to characterize the HA-induced capacity,and MTS method was adopted to evaluate the adhesion and proliferation behaviors of the osteoblast cells. Results In vitro experimental results showed that the mineralized collagen coating was stable in simulated body fluid（ SBF）,and it could promote the adhesion,proliferation and differentiation of the osteoblast precursor cells. Conclusions Modification of the mineralized collagen coating on titanium implant surface can effectively promote its biological activity.

关 键 词：电化学沉积 矿化胶原 钛基板 

分 类 号：R783.1[医药卫生—口腔医学]