精神分裂症患者与健康同胞及正常人群认知功能的比较  

Cognitive functioning impairment in patients with schizophrenia and their unaffected siblings

作　　者：高丽娟[1] 贾福军 张振娟[1] 钟潇潇 

机构地区：[1]广东佛山市第三人民医院,528000 [2]广东省精神卫生研究所

出　　处：《临床精神医学杂志》2015年第5期335-337,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨精神分裂症患者与健康同胞及正常对照人群认知功能的特点。方法:采用数字划消测验(CT)、修订韦氏成人记忆量表(WMS-RC)、威斯康星卡片分类测验(WCST)对35例精神分裂症患者(患者组)、35例患者健康同胞(同胞组)及30例健康对照组(对照组)的认知功能进行测验。结果:患者组与同胞组记忆商数差异无统计学意义(P>0.05);而与对照组记忆商数差异有统计学意义(P<0.05)。在划消测验上患者组和同胞组指向与转移因子间差异有统计学意义(P<0.05),而选择因子差异无统计学意义(P>0.05);患者组和对照组在指向、转移与选择3个因子差异均有统计学意义(P<0.05)。在WCST上患者组和同胞组持续时间数和持续错误数差异无统计学意义(P>0.05),而分类完成数和总测验次数差异有统计学意义(P<0.01);患者组与对照组比较,持续时间数、持续错误、分类完成数、总测验次数均差异有统计学意义(P<0.01)。结论:精神分裂症患者及其健康同胞存在注意、记忆、执行功能方面的损害。Objective： To study the cognitive function in patients with schizophrenia and their siblings. Method：Thirty five patients with schizophrenia,35 siblings of the patients, and 30 normal controls were en- rolled in the study. Attention, working memory and executive function were measured with the cancellation test （ CT）, Wechsler memory scale （WMS） and Wisconsin card sorting test （ WCST ）, respectively. Results：Pa- tients and their siblings showed no significant difference on MQ （P 〉 0.05） but lower MQ than the nomlal con- trois （ P 〈 0.05 ）. Patients and their siblings did not demonstrated significant difference on selection （ P 〉 0.05 ） but on direction and transference in cancellation test （ P 〈 0.05 ） ; the significant differences were found on se- lection, direction and transference between patients and controls （ P 〈 0. 05 ）. Patients and their siblings did not showed significant difference on perseverative times and errors （P 〉 0.05 ） but on numbers and categories a- chieved in WCST （ P 〈 0.05 ） ; there were significant differences on perseverative times, perseverative errors, numbers and categories achieved between patients and controls （P 〈 0.05 ）. Conclusion： Patients with schiz- ophrenia and their unaffected siblings have attention ,working memory and executive function impairment.

关 键 词：精神分裂症 同胞关系 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]