CISD2在早期宫颈腺癌中的表达和临床意义  

Expression of CISD2 in Early-stage Cervical Adenocarcinoma and Its Clinical Significance

作　　者：刘璐欣[1] 何勉[1] 刘军秀[1] 夏梦[1] 王晶[1] 

机构地区：[1]中山大学附属第一医院妇产科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2015年第5期728-733,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省自然科学基金(S2013010015552)

摘　　要：【目的】:探讨CISD2在早期宫颈腺癌组织中的表达及其与临床特征的关系。【方法】采用免疫组织化学染色法分析CISD2在56例FIGO分期为IB-IIA期的早期宫颈腺癌组织中的表达,并以3例正常宫颈组织作为阴性对照。运用统计学分析CISD2表达水平与早期宫颈腺癌的临床病理特点与预后的关系。【结果】CISD2在FIGO分期为IB-IIA期的早期宫颈腺癌患者组织中44.6%为高表达,55.4%为低表达,在正常宫颈组织中不表达。CISD2的表达水平与早期宫颈腺癌患者深肌层浸润(P=0.023),淋巴结转移(P=0.003)和卵巢转移(P=0.014)有明显相关。高表达CISD2的早期宫颈腺癌患者5年生存率明显低于CISD2低表达患者(P=0.002)。多因素分析提示CISD2的表达水平是早期宫颈腺癌患者总体生存期的独立预测指标(P=0.027)。【结论】在早期宫颈腺癌患者中CISD2的表达与临床特征和预后有关,它可能是一种新的预测早期宫颈腺癌患者预后的分子标志物。【Objective】 This study aimed to investigate the expression of CISD2 in early-stage cervical adenocarcinoma tissues and its association with the clinical features. 【Methods】 CISD2 expression was examined by immunohistochemical method in 56 cases of early-stage（FIGO stage IB-IIA） cervical adenocarcinoma tissues, and 3 cases of normal cervical tissues were used as negative control. Statistical analyses were performed to evaluate the association between CISD2 expression and the clinicopathological characteristics and prognosis of early-stage cervical adenocarcinoma. 【Results】 CISD2 expression was positive in early-stage（FIGO stage IB-IIA） cervical adenocarcinoma tissues ： CISD2 high expression accounted for 44.6% and CISD2 low expression was 55.4%,but negative in normal cervical tissues. The level of CISD2 expression was significantly correlated with deep myometrium invasion（P =0.023）, lymph node metastasis（P = 0.003） and ovarian metastasis（P = 0.014）. Patients with high CISD2 expression had a lower 5-year survival rate than patients with low CISD2 expression（P = 0.002）. Multivariate analysis suggested that CISD2 expression was an independent prognostic marker for survival in patients with early-stage cervical adenocarcinoma（P = 0.027）. 【Conclusion】 CISD2 expression was closely associated with clinical features and prognosis, and it might be a novel biomarker for the prediction of prognosis of early-stage cervical adenocarcinoma.

关 键 词：CISD2 早期宫颈腺癌 预后标志物 

分 类 号：R737.33[医药卫生—肿瘤]