正常人视乳头中央筛板厚度的活体测量  

Central Laminar Cribrosa Measurement in Healthy Chinese in Vivo

作　　者：肖辉[1] 刘杏[1] 徐晓宇[1] 钟毅敏[1] 

机构地区：[1]中山大学中山眼科中心//眼科学国家重点实验室,广东广州510060

出　　处：《中山大学学报（医学科学版）》2015年第5期786-790,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省医学科研基金(B2013139)

摘　　要：【目的】获得正常人中央筛板厚度的活体测量结果并分析性别、眼别、年龄对其的影响。【方法】收集正常人85例85眼进行常规眼部检查及频域光学相干断层扫描仪（SDOCT）检查,采用增强型深度成像（EDI）模式对视乳头中央进行水平和垂直线性扫描,选取图像清晰者保存。获取正常人中央筛板厚度（LCT）的活体数据;比较不同性别、眼别间筛板厚度的差异;比较不同年龄段筛板厚度的差异;相关分析法分析屈光度、眼压及年龄与筛板厚度的相关性。【结果】总体正常人平均年龄（50±18）岁,平均筛板厚度（232±41）μm。正常人中男性45例45眼,女性40例40眼,不同性别间筛板厚度无统计学差异（P=0.71）;右眼40眼,左眼45眼,不同眼别间筛板厚度无统计学差异（P=0.36）;按年龄将患者分为3组：20-39、40-59、60岁及以上;3组的平均筛板厚度分别为（211±24）、（220±30）、（256±46）μm,3组间差异有统计学差异（P〈0.001）;年龄与筛板厚度正相关（r=0.46,P〈0.001）。眼压及屈光度对筛板厚度无显著影响（r=0.06-0.10,P=0.35-0.45）。【结论】正常人不同性别、眼别间筛板厚度没有显著差异。年龄对筛板厚度有一定影响,年龄越大筛板越厚,在疾病分析时应注意年龄对筛板的影响。【Objective】 To obtain the lamina cribrosa thickness（LCT） in healthy Chinese subjects in vivo and analyze the impact of gender, eye, age on LCT. 【Methods】 A total of 85 eyes from 85 subjects with no ophthalmic disease history were recruited. Lamina cribrosa image were obtained from all eyes using enhanced depth imaging spectral-domain optical coherence tomography（EDI SDOCT）. The LCT was averaged from horizontal and vertical linear scanning. The differences of the LCT of different gender, eye and age were analyzed. The relationships between LCT and intraocular pressure（IOP）,refractive error, as well as age, were analysed.【Results】 For the whole normal subjects, the overall mean age was 50 ± 18 years, the average LCT was 232 ± 41 μm. No statistically significant difference in LCT was found between the genders（P = 0.71） and different eyes（P = 0.36）. According to age, the subjects were divided into three groups： G1（20 ~ 39, 40 ~ 59, 60 ~ 80 years）. The average LCT of the three groups were 211 ± 24, 220 ±30, 256 ± 46 μm, respectively, with statistically significant differences among the three groups（P0.001）. Age was positively correlated with LCT（r = 0.46, P〈0.001）. IOP and refractive error have no significant effects on the LCT（r = 0.06 ~0.10,P = 0.45）【Conclusion】 No significant impact of gender and eye was found on LCT. Age may influence the LCT. The impact of age on the lamina cribrosa should be considered when analyzing disease states.

关 键 词：筛板 光学相干 摄影术 年龄 

分 类 号：R77[医药卫生—眼科]