原发性失眠患者的情绪记忆改变  被引量:15

Characteristics of emotional memory impairment in patients with primary insomnia

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作  者:李雪[1] 朱幼玲[1] 席春华[1] 董斌[1] 张婷婷[1] 翟登月[1] 唐敏[1] 

机构地区:[1]安徽医科大学第三附属医院,合肥市第一人民医院神经内科,合肥230061

出  处:《中华行为医学与脑科学杂志》2015年第10期892-895,共4页Chinese Journal of Behavioral Medicine and Brain Science

基  金:国家自然科学基金项目(81301095);合肥市第四周期医学重点学科项目(卫科2013-206号)

摘  要:目的了解原发性失眠(primaryinsomnia,PI)患者情绪记忆的改变,初步探讨不同情绪效价对PI患者的记忆影响模式。方法使用不同效价的情绪图片学习一再认任务分别对30名PI患者(PI组)和20名健康对照组(HC组)进行情绪记忆测试。结果在学习阶段,PI组的情绪图片评分成绩(分别为:正性(11.30±3.75)分;中性(11.47±3.21)分;负性(11.43±4.12)分)与HC组相比(正性(11.60±4.00)分,中性(11.05±3.73)分,负性(12.60±2.06)分),差异无统计学意义(均P〉0.05)。在再认阶段,PI组总情绪图片再认正确得分较HC组明显下降[分别为:(39.40±6.43)分和(43.40±4.88)分],差异有统计学意义(P〈0.05)。PI组对不同效价情绪图片再认存在分离现象,相对于正常对照组,PI组在正性情绪图片再认[分别为PI组:(12.60±2.42)分;HC组:(14.05±2.19)分]和中性情绪图片再认[分别为PI组:(12.87±3.18)分;HC组:(14.75±1.80)分]正确得分明显下降,差异有统计学意义(均P〈0.05);而两组负性情绪效价图片的再认正确得分[分别为PI组:(13.93±1.76)分;HC组:(14.70±1.59)分]的差异无统计学意义(P〉0.05)。结论PI患者存在情绪记忆的损害,主要表现为正性、中性情绪记忆受损,而负性情绪记忆相对保留,提示PI对不同效价情绪记忆的影响可能依赖不同的神经机制。Objective To investigate the emotional memot'y impairment in patients with primary insomnia (PI) and explore the neurobiological mechanisms underlying primary insomnia through emotional memory tasks involving different valance of emotional pictures. Methods Thirty patients with primary insomnia ( PI group ) and twenty healthy controls (HC group) were given emotional memory tasks using positive, neutral and negative valence images. The emotional memory was evaluated by the recognition of emotional pietures. Results Compared with healthy eontrols( positive ( 11.60±4.00), neutral ( 11.05±3.73 ) and negative (12.60±2.06) , respectively ) , patients with PI ( positive (11.30±3.75),neutral (11.47±3.21) and negative (11.43±4.12),respectively) showed no significant difference in appraisal of the emotional pictures (P〉0.05). Compared with healthy controls (43.40± 4.88) for the emotional images memorizing task,patients with PI (39.40±6.43) exhibited evident deficit of all emotional images (P〈 0.05). Furthermore, the accuracy in recognizing both positive (12.60± 2.42) and neutral (12.87±3.18) valence pictures were signifieantly lower in patients with PI than those in healthy controls (positive (14.05±2.19) and neutral ( 14.75± 1.80) ) (P〈0.05). There was no significant differenee in negative stimulus between PI group(13.93±1.76) and HC group(14.70±1.59) (P〉0.05). Conclusion The results suggest that emotional memory is impaired in patients with PI. Moreover, the emotional memory for positive and neutral vanlenee pictures is impaired but the emotional memory for negative is relatively spared in patients with primary insomnia. The results also indicate that impaired emotional memory with different valences may relate with distinct neuromechanisms.

关 键 词:原发性失眠 情绪 记忆 神经心理学测试 

分 类 号:R740[医药卫生—神经病学与精神病学]

 

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