双相抑郁和单相抑郁患者及其一级亲属认知功能研究  

Study on cognitive function of the patients with bipolar depression and unipolar depression and their firstdegree relatives

作　　者：姚静[1] 周为[1] 金敏[1] 刘从敏[1] 赵思柔 吴林林[1] 雷兴旺 

机构地区：[1]绵阳市第三人民医院精神科,绵阳621000

出　　处：《中华行为医学与脑科学杂志》2015年第10期925-927,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：绵阳市应用技术研究与开发基金项目（06S042-08）

摘　　要：目的探讨双相抑郁和单相抑郁患者及其一级亲属的认知功能。方法对52名双相抑郁患者、67名单相抑郁患者、49名双相抑郁患者的一级亲属、59名单相抑郁患者的一级亲属、97名正常对照组进行知识、算术、数字符号、数字广度、木块拼图、视觉记忆、逻辑记忆、Stroop色词命名测验（包括颜色干扰测验和字义干扰测验）、连线测验（包括A、B测验）、威斯康辛卡片分类测验（WCST）。结果双相抑郁患者和单相抑郁患者在数字符号、木块拼图、即刻逻辑记忆、延迟逻辑记忆、即刻视觉记忆、延迟视觉记忆、连线测验B、WCST正确分类数上明显差于正常组（均P〈0．01）。双相抑郁患者WCST正确分类数低于单相抑郁患者组[（3．02±1．96）个、（4．40±1．13）个，P〈0．01]，双相抑郁患者一级亲属组WCST正确分类数低于正常组[（4．32±1．66）个、（5．15±1．27）个，P〈0．05]。结论双相抑郁患者和单相抑郁患者在持续注意、视觉空间概念、视觉记忆、言语记忆、执行功能上存在类似的认知功能受损模式，前者比后者在执行功能受损上更为严重。Objective To explore the cognitive function of the patients with bipolar depression （ BP）, unipolar depression （UP） and their first-degree relatives. Methods 52 patients with BP and 49 their first-degree relatives, 67 patients with UP and 59 their first-degree relatives, 97 normal controls were tested by information, arithmetic, digital symbol, digital span test, block design, logical memory （ included immediately and delayed） , visual memory（included immediately and delayed）,Stroop Test（ included Stroop C and Stroop CW）, trail making test （included Part A and Part B）, verbal fluency and modified Wisconsin card sorting test（M-WCST） .Results The scores of digital symbol, block design, immediately logical memory, delayed logical memory, immediately visual memory,delayed visual memory, trail making test B and WCST in the patients with BP and UP were worse than those in normal control（P〈0.01 ）.The score of WCST in the patients with BP was lower than that in the patients with UP （（3.02± 1.96）, （4.40±1.13）, P〈0.01）. The score of WCST in the relatives of the patients with bipolar depression was worse than that in the normal control（ （4.32±1.66）, （5.15±1.27）, P〈 0. 05 ） . Conclusion The patterns of impaired cognitive function on sustained attention, concept of visual space, visual memory, verbal memory and executive function are similar in the patients with BP and UP. The executive function of the patients with BP is worse than the patients with UP.

关 键 词：双相抑郁 单相抑郁 一级亲属 认知 

分 类 号：R749.4[医药卫生—神经病学与精神病学]