CerbB2、ER、PR、Ki67在乳腺癌中的表达及意义  

Expression and significance of erbB2, ER, PR, Ki67 in breast cancer

作　　者：付勇先[1] 范瑞[1] 郑香玉[1] 高峰[1] 孙征[1] 孙冉[1] 

机构地区：[1]河南省南阳市第一人民医院病理科,473000

出　　处：《中国实用医刊》2015年第21期80-82,共3页Chinese Journal of Practical Medicine

摘　　要：目的：分析CerbB2、ER、PR、Ki67在乳腺癌中的表达及其意义。方法抽取南阳市第一人民医院经临床病理证实的乳腺癌患者90例作为乳腺癌组，取同期乳腺良性病者87例作为对照组，两组患者入院后均行免疫组化检查，并记录CerbB2、ER、PR、Ki67表达。结果乳腺癌组CerbB2、ER、PR、Ki67基因的阳性表达率分别为60．0％、48．89％、55．56％、72．22％，均显著高于对照组，差异具有统计学意义（ P＜0．05）。腋窝淋巴转移患者的CerbB2、PR、Ki67阳性率为50．98％、33．33％、90．20％，与对照组比较，差异均有统计学意义；浸润性导管癌患者CerbB2、Ki67阳性率分别为21．05％、47．37％，显著低于浸润性小叶癌、髓样癌， ER、PR阳性率分别为89．47％、78．95％，显著高于浸润性小叶癌、髓样癌，差异均有统计学意义（ P＜0．05）。结论 CerbB2、ER、PR、Ki67表达对乳腺癌诊断、治疗具有指导意义，可作为预后评估指标。Objective To analyze the expression and significance of CerbB2, ER, PR, Ki67 in breast cancer. Methods Selected 90 cases proved by pathology as breast cancer as cancer group, and 87 cases over the same period of benign breast disease as control group. Patients of the two groups underwent immunohistochemieal examination after admis- sion, and recorded the expression of CerbB2, ER, PR, Ki67 gene. Results Positive expression of CerbB2, ER, PR, Ki67 gene in breast cancer group was 60% , 48.89% , 55.56% , 72. 22%, whieh were higher than those in the control group, there were significant differences（P 〈 0. 05）. CerbB2, PR, Ki67 positive rate of axillary lymphatic metastasis pa- tients was 50. 98% , 33.33%, 90. 20%, which were significantly different between the control group and cancer group; CerbB2, Ki67 positive rates of invasive ductal cancer patients were 21.05% and 47.37% , which were significantly lower than those of invasive lobular eareinoma, medullary carcinoma; the positive rates of PR and ER were 89.47% and 78.95% , which were significantly higher than those of invasive lobular carcinoma, medullary carcinoma, and the differ- ences were significant （P 〈 0. 05 ）. Conclusions Expression of CerbB2, ER, PR, Ki67 has guiding significance in the di- agnosis and treatment of breast cancer, it can be used as the index of evaluating, nro^nosis.

关 键 词：乳腺癌 免疫组化方法 CERBB2 ER PR KI67 

分 类 号：R730.3[医药卫生—肿瘤]