TRPV4通道与脑缺血再灌注损伤的研究进展  

Research progress of TRPV4 and cerebral ischemic reperfusion injury

作　　者：丁浩[1] 林叶昕 沈绮雯 潘智[1] 王振超[1] 陈蕾[2] 

机构地区：[1]南京医科大学2012年级七年制临床医学系4班,南京210029 [2]南京医科大学生理学系,南京210029

出　　处：《生理学报》2015年第5期527-532,共6页Acta Physiologica Sinica

基　　金：supported by grants from the University Students’ Innovative Entrepreneurial Training Project of Jiangsu Province,China(No.201410312026Z);the National Natural Science Foundation of China(No.31271206);Qinglan Project of Jiangsu Province,China(2014–2017)

摘　　要：香草素受体4型瞬时感受器电位通道(transient receptor potential vanilloid 4 channel,TRPV4通道)是瞬时感受器电位通道家族成员之一。TRPV4通道是一种对钙离子具有选择通透性的阳离子通道,该通道激活后可以引起胞内钙离子浓度升高,进而参与调节机体多种生理或病理过程。现已证明,TRPV4通道可能在脑缺血再灌注所致的神经损伤中发挥重要作用。本文对近年来有关TRPV4通道与脑缺血再灌注损伤方面的研究进展予以综述。Transient receptor potential vanilloid 4 （TRPV4） channel is a member of transient receptor potential superfamily. TRPV4 is selectively permeable to calcium. Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Especially, there is evidence showing that TRPV4 is involved in cerebral ischemic reperfusion injury. The present paper reviewed some research progress about the role of TRPV4 in cerebral ischemic reperfusion injury.

关 键 词：TRPV4通道 钙离子 脑缺血再灌注 

分 类 号：R743.3[医药卫生—神经病学与精神病学]