正畸扭转力对成人牙髓中TNF-α活性影响的研究  

The effect of orthodontic torsional force on TNF-α expression in adult dental pulps

作　　者：郭新星[1] 陈静[2] 张勇[1] 

机构地区：[1]济南市口腔医院正畸科,山东济南250001 [2]山东大学口腔医院,山东济南250012

出　　处：《牙体牙髓牙周病学杂志》2015年第10期615-617,623,共4页Chinese Journal of Conservative Dentistry

基　　金：济南市科技卫生计划项目(2008-31)

摘　　要：目的：通过TNF-α的活性变化来评价正畸扭转力对成人牙髓组织状况的影响。方法：随机选取矫治设计为拔除两侧上颌第一前磨牙的20～28岁患者56例,共112个牙,随机分为实验组（n=96）和对照组（n=16）。实验组根据交互牵引正畸扭转力值的不同又分为4、6、8盎司组,分别于加力1、2、3、4周时拔牙并取牙髓标本;对照组不加力,分别于实验组相同时间内拔牙并取牙髓标本。用光度酶联免疫分析法（ELISA）测定牙髓中TNF-α的含量及牙髓在矫治过程中的变化。结果：4、6盎司组在扭转力加载1、2、3周时TNF-α含量基本无变化;持续加载4周后,TNF-α含量增加（P〈0.05）。8盎司组在持续扭转力作用2周后,TNF-α含量迅速增加到最大（P〈0.05）,3周时,TNF-α含量减低,与对照组相比无统计学差异（P〉0.05）。结论：持续扭转力过大或时间过长可能会引起牙髓TNF-α的活性变化。AIM： To investigate the effects of orthodontic torsional force on TNF-α expression in adult dental pulps. METHODS： 112 maxillary first premolars in 56 adult orthodontic patients were randomly divided into experimental group（ n = 96） and control group（ n = 16）. The teeth in experimental group were added with 4,6,and 8ounces orthodontic torsional force for 1,2,3 and 4 w respectively（ n = 8）. At the end of the treatment,the teeth were extracted and dental pulp tissues were removed. TNF- α expression in the dental pulps were detected by ELISA.RESULTS： In 4 and 6 ounce torsional force treatment groups TNF-α expression did not show any change up to 3 w,but increased at the end of 4 w in the 2 groups（ P〈0. 05）. However,TNF-α expression significantly increased at the end of 2 w in the 8 ounce torsional force treatment group（ P〈0. 05）,and decreased to control level at the end of 3 and4 w. CONCLUSION： Torsional force may change TNF-α expression in adult dental pulp.

关 键 词：扭转 牙髓 肿瘤坏死因子-α(TNF-α) 正畸 

分 类 号：R780.2[医药卫生—口腔医学]