生物体系的多层次计算设计与合成生物学  

Computation and Design of Biological Systems at Different Levels in Synthetic Biology

作　　者：刘海燕[1] 黄斌[1] 

机构地区：[1]中国科学技术大学生命科学学院,合肥230027

出　　处：《中国科学：生命科学》2015年第10期943-949,共7页Scientia Sinica(Vitae)

基　　金：国家重点基础研究发展计划(批准号:2011CBA00803);国家自然科学基金委员会-中国科学院学科发展战略研究合作项目(批准号:L1222037);中国科学院合肥大科学中心研究项目(批准号:2015SRG-HSC041)资助

摘　　要：合成生物学的核心思想是将现代工程学的原理与方法引入对生命系统的改造和构建中.生命活动覆盖从分子到细胞再到有机体等不同层次.合成生物学研究同样跨越了多个层次,例如,在分子层次进行生物元件和器件的设计和标准化、通过合成基因线路研究生物网络的设计和调控原理、在途径和网络层次进行细胞内代谢网络和代谢途径的人工设计改造等.本文一方面试图对与此有关的既有计算机模拟与设计方法加以总结和介绍,另一方面探讨这些不同层次的计算模拟与设计工具可应用于哪些方面的合成生物学问题,以及既有方法可能在哪些方向上还有比较大的发展潜力,能更好满足合成生物学研究需求.A central goal of synthetic biology is to integrate the principles and approaches of modern engineering sciences into the engineering of biological systems. The functioning of living systems spans different levels, ranging from molecules to cells and, eventually, the organism. Synthetic biology studies cover the same range, including the design and standardization of molecular parts and devices at the molecular level and the study of design principles of cellular networks by using synthetic gene circuits or the design and implementation of artificial metabolic pathways for biosynthesis at the network level. We briefly introduce related computational approaches applicable at these two levels. In our discussions, we attempt to explore the means by which existing computational approaches may be applied in synthetic biology and elucidate the potential developments in computational tools that would improve them such that they meet the needs of synthetic biology studies.

关 键 词：生物信息学方法 分子设计 网络动力学 代谢网络分析 

分 类 号：Q811.4[生物学—生物工程]