脱落乳牙牙髓干细胞的生物学特性  

Biological characteristics of stem cells from human-exfoliated deciduous teeth

作　　者：谷楠[1] 孙鑫[1] 刘富萍[1] 张宇娜[1] 张雪[1] 李海鹰[1] 

机构地区：[1]吉林大学口腔医院儿童口腔科,长春130021

出　　处：《国际口腔医学杂志》2015年第6期715-719,共5页International Journal of Stomatology

摘　　要：在乳恒牙交替过程中,乳牙不断脱落,即脱落乳牙牙髓干细胞(SHED)获取容易,且SHED较骨髓间质干细胞和牙髓干细胞有更强的细胞增殖能力。SHED含有的成纤维细胞生长因子、转化生长因子-β、结缔组织生长因子、神经生长因子、骨形态发生蛋白等促进SHED增殖。SHED可向成牙本质细胞、神经细胞、软骨细胞、脂肪细胞和肝细胞向分化及诱导宿主细胞分化为成骨细胞,还有免疫调节和促进伤口愈合功能,是理想的骨组织工程和皮肤组织工程种子细胞。有鉴于此,SHED在治疗牙体缺失、骨缺损,神经系统疾病和免疫系统疾病,皮肤外伤和肝脏疾病方面有着广泛的应用前景。Deciduous teeth are constantly exfoliated in the alternate process of deciduous and permanent teeth. Hence, obtaining stem cells from human-exfoliated deciduous teeth（SHED） is simple and convenient. The proliferation rate of SHED was significantly higher than that of dental pulp stem cells and bone marrow mesenchymal stem cells. SHED expressed several growth factors for promoting proliferation, such as fibroblast growth factor, transforming growth factor-13, connective tissue growth factor, nerve growth factor, and bone morphogenetic protein. SHED are able to differentiate into odontoblasts, neural cells, cartilage cells, adipocytes, and liver cells, and can induce host cells to regenerate bone. In addition, SHED have immune modulatory effects and can enhance wound-healing effects. SHED are ideal seed cells for bone and skin tissue engineering. Thus, SHED can potentially be used for treating tooth and bone defects, nervous system diseases, immune system diseases, skin trauma, and liver diseases.

关 键 词：脱落乳牙牙髓干细胞 多向分化 组织再生 

分 类 号：R78[医药卫生—口腔医学]