^(99m)Tc-MIBI脑肿瘤阳性显像联合MRI成像对胶质瘤术后残留复发的诊断价值  

Evaluation of the diagnostic value of ^(99m)Tc-MIBI SPECT positive tumor imaging and MRI in the recurrence or postoperative residual lesions of glioma

作　　者：张伟晓 许小飞[1] 盛丹丹[1] 王成[1] 周玲玲[1] 刘雅洁[1] 

机构地区：[1]南京医科大学第二附属医院核医学科,210011

出　　处：《实用医学杂志》2015年第18期2997-3000,共4页The Journal of Practical Medicine

摘　　要：目的:评价99m Tc-MIBI脑肿瘤阳性显像及MRI诊断胶质瘤术后残留复发的价值。方法:30例胶质瘤术后患者,经病理活检或临床随访证实为术后残留复发者21例,无残留复发者9例,所有患者行99mTcMIBI SPECT脑肿瘤阳性显像及MRI平扫或增强,分析两种方法的诊断效能。结果 :99mTc-MIBI脑显像诊断胶质瘤术后残留复发的灵敏度低于MRI检查(81.0%vs.90.5%,χ2=0.006 4,P=0.035),但特异性明显高于MRI检查(88.9%vs.77.8%,χ2=3.827,P=0.006)。两者诊断胶质瘤术后残留复发的准确性无明显差异(χ2=2.149,P=0.153)。99mTc-MIBI脑肿瘤阳性显像与MRI联合诊断胶质瘤术后残留复发的灵敏度、特异性及准确性分别为95.2%、100%、93.3%,两者联合应用明显提高了诊断的准确性。结论:99mTc-MIBI脑肿瘤阳性显像诊断胶质瘤术后残留复发有较高的特异性,与MRI联合应用可明显提高诊断的准确性,具有较高的临床价值。Objective To evaluate the value of 99mTc-MIBI SPECT positive tumor imaging and MRI in the diagnosis of recurrence and postoperative residual of glioma. Methods Of 30 cases of glioma, 21 cases were residual or recurrent of glioma, while 9 cases were not, confirmed by pathology or follow-up.99mTc-MIBI SPECT positive tumor imaging and MRI were performed on all patients. Results The sensitivity of 99mTc-MIBI SPECT positive tumor imaging（80.1%）was lower than that of MRI（90.5%）（χ2= 0.006 4,P = 0.035）, while the specificity of 99mTc-MIBI SPECT（88.9%） was much higher than that MRI（77.8%）（χ2= 3.827,P = 0.006）. The accuracy in diagnosing residual or recurrent glioma between the two imaging has no significant difference. The sensitivity, specificity and accuracy were 95.2%, 100% and 93.3% when the two imaging methods were combined. Conclusions 99mTc-MIBI SPECT positive tumor imaging has higher specificity in the diagnosis of recurrence and postoperative residual of glioma. The combination of 99mTc-MIBI SPECT positive tumor imaging and MRI has great clinical significance.

关 键 词：胶质瘤 肿瘤复发 99MTC-MIBI MRI 

分 类 号：R739.4[医药卫生—肿瘤] R730.44[医药卫生—临床医学] R445.2