环氧化酶-2及细胞因子在创伤后应激障碍患者中的表达变化及意义  

Expression and significance of serum cyclooxygenase-2 and cytokine in patients with post-traumatic stress disorder

作　　者：何主强[1] 殷莉[2] 黄珊珊[3] 

机构地区：[1]武汉市第一医院神经外科,430022 [2]华中科技大学同济医学院附属同济医院妇产科,武汉市430030 [3]华中科技大学同济医学院附属同济医院神经内科,武汉市430030

出　　处：《实用医学杂志》2015年第19期3166-3168,共3页The Journal of Practical Medicine

基　　金：湖北省自然科学基金(编号:2015CFB694)

摘　　要：目的:初步探讨创伤后应激障碍(PTSD)患者血清中白细胞介素(IL)-1、IL-6、肿瘤坏死因子-α(TNF-α)与环氧化酶-2(COX-2)的表达变化及意义。方法:收集32例PTSD患者(PTSD组)与26例健康体检者(对照组),采用酶联免疫吸附法(ELISA)与Western blot法对PTSD组血清中IL-1、IL-6、TNF-α及COX-2进行检测,并与对照组进行比较。结果:PTSD组血清IL-1、IL-6及TNF-α水平明显高于对照组(P<0.01);COX-2含量水平也明显高于对照组(P<0.01)。结论 :PTSD患者存在显著的免疫功能紊乱,IL-1、IL-6、TNF-α及COX-2可能在PTSD的发病机制中起着重要作用。Objective To investigate the significance of variation of concentrations of serum IL-1,IL-6, TNF-α and cyclooxygenase-2 in patients with post-traumatic stress disorder （PTSD）. Methods Thirty-two PTSD patients were chosen as the observation group and another 26 normal patients were taken as the control group. The concentrations of serum IL-1 ,IL-6,TNF-α arid COX-2 in patients of both groups were detected by Enzyme- linked immunosorbent assay （ELISA） and Western blot and were compared in these 2 groups. Results The concentrations of serum IL-1, IL-6 and TNF-α were significantly higher in the observation group than those in the control group （P 〈 0.01 ）;and the level of COX-2 in the observation group was significantly higher than that of the control group（P 〈 0.01 ）. Conclusions Abnormal immune states are awared in PTSD patients and the IL- 1 , IL-6, TNF-α and COX-2 might play an important role in the pathogenesis of PTSD.

关 键 词：应激障碍 创伤后 细胞因子 环氧化酶-2 氧化应激 

分 类 号：R749.5[医药卫生—神经病学与精神病学]