动脉灌注化疗对局部晚期鼻咽癌的近期疗效  

Early clinical effect of intra-arterial induction chemotherapy on Locally advanced nasopharyngeal carcinoma

作　　者：陈建武[1] 张幸平[2] 刘德鑫[3] 肖丽华[1] 吴敏[1] 苏菁菁[1] 郑建清[1] 

机构地区：[1]福建医科大学附属第二医院放疗科,泉州362000 [2]重庆医科大学附属第一医院肿瘤科,重庆400016 [3]福建医科大学附属第二医院放射科,泉州362000

出　　处：《安徽医科大学学报》2015年第11期1696-1698,共3页Acta Universitatis Medicinalis Anhui

基　　金：福建省自然科学基金(编号:2011J01155);福建省医学创新课题(编号:2009cx-10)

摘　　要：将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗(IAC)组和静脉诱导化疗联合放疗(IVC)组。治疗后4周,IAC组与IVC组的完全缓解(CR)率分别为94.0%、70.0%,差异有统计学意义(P<0.05);治疗后12周,IAC组与IVC组的CR率分别为98.0%、72.0%,差异有统计学意义(P<0.05)。两组治疗有效率均为100%,均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较,差异无统计学意义(P>0.05)。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy. After 4 weeks,the complete remission rate（ CR） in group IAC and IVC was 94. 0% vs 70. 0%,with statistical significance（ P〈0. 05）,and at 12 weeks,98. 0% vs 72. 0%,with statistical significance（ P〈0. 05）. The effective rate of the two groups was both 100%,and there was no distant metastasis. 3,4 grade of acute toxicity incidence in Group IAC and Group IVC was 32. 0% and 34. 0%,respectively,without statistical significance（ P〉0. 05）. Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely.

关 键 词：动脉灌注 放化疗 局部晚期鼻咽癌 近期疗效 

分 类 号：R737.62[医药卫生—肿瘤]