奈达铂周剂量化疗同步放疗治疗老年食管癌的疗效  

Efficacy of nedaplatin-weekly chemotherapy combined with radiotherapy in treating elderly patients with esophageal carcinoma

作　　者：陈志明[1] 陈晓珏[1] 薛强[1] 季斌[1] 施健[1] 陈不尤[1] 马剑波[1] 

机构地区：[1]南通大学附属医院肿瘤放疗科,江苏省226001

出　　处：《江苏医药》2015年第20期2423-2425,共3页Jiangsu Medical Journal

摘　　要：目的观察奈达铂周剂量化疗同步放疗治疗老年食管癌的疗效。方法 83例老年食管癌患者随机分为两组:A组41例,采用周剂量奈达铂30mg/m2化疗5周和同步放疗;B组42例,单纯放疗。比较两组疗效及不良反应。结果A组治疗有效率高于B组(85.4%vs.71.4%)(P<0.05)。随访2.3-75.0个月,随访率达96.4%。A组1、3、5年无进展生存率及1、3、5年总生存率均高于B组(P<0.01)。A组白细胞下降2-3级及血小板下降发生率均高于B组(P<0.05),但两组均未出现4级不良反应。结论奈达铂周剂量化疗同步放疗治疗老年食管癌疗效好;虽然加重骨髓抑制,但耐受性良好。Objective To observe the efficacy of nedaplatin（NDP）-weekly chemotherapy combined with radiotherapy in treating elderly patients with esophageal carcinoma.Methods Eightythree elderly patients with esophageal carcinoma were randomly divided into two groups of A（NDP 30mg/m2 weekly for 5 weeks combined with radiotherapy,41cases）and B（radiotherapy alone,42cases）.Clinical efficacy and adverse effects were compared between two groups.Results Effective rate was higher in group A than that in group B（85.4%vs.71.4%）（P〈0.05）.The patients were followed up for 2.3-75.0months with 96.4% of follow-up rate.Progress free survival rate and overall survival rate in the 1st,3rd and 5th year in group A were higher than those in group B（P〈0.01）.Incidences of leukocyte decrease at 2-3level and platelet descend in group A were higher than those in group B（P〈0.05）,but there were no 4level of adverse effects in two groups.Conclusion NDP-weekly chemotherapy combined with radiotherapy has better efficacy than radiotherapy alone in treating elderly patients with esophageal carcinoma.The bone marrow suppression is increased,but is well tolerated.

关 键 词：食管癌 奈达铂 老年 

分 类 号：R735[医药卫生—肿瘤]