nesfatin-1与2型糖尿病共病抑郁症的相关性研究  

The correlation study of nesfatin-1 and type 2 diabetes mellitus complicated with depression

作　　者：王高华[1] 魏艳艳[1] 王惠玲[1] 肖敏敏 桂瑰[1] 李江波 

机构地区：[1]武汉大学人民医院精神卫生中心,武汉430060 [2]芜湖市第二人民医院检验科 [3]芜湖市第二人民医院临床心理科

出　　处：《国际精神病学杂志》2015年第5期1-4,共4页Journal Of International Psychiatry

基　　金：国家科技部十二.五科技支撑计划项目(2012BAI01B05);国家高技术研究发展计划(863计划)(2014AA022304)

摘　　要：目的探讨nesfatin-1与2型糖尿病共病抑郁症的相关性。方法选取2型糖尿病(T2DM)患者77例,根据抑郁症诊断标准分为T2DM共病抑郁症组25例(DDM组)、T2DM非抑郁症组52例(NDDM组);以年龄、性别相匹配的30例健康体检者为正常对照组(NC组)。用汉密尔顿抑郁量表(HAMD)测量,并检测血浆nesfatin-1、空腹血糖(FPG)、血脂、空腹胰岛素(FINS)等水平。比较三组nesfatin-1水平变化,分析其与HAMD分数及其他指标的相关性。结果 DDM组nesfatin-1水平明显高于NDDM组及NC组(P<0.01)。T2DM患者(77例)nesfatin-1水平与HAMD分数、C肽、甘油三酯(TG)呈显著正相关(P<0.05)。回归分析示HAMD分数、TG和低密度脂蛋白-胆固醇(LDL-C)是影响nesfatin-1水平的独立相关因素(P<0.05);nesfatin-1与DDM密切相关(OR=1.140,P<0.01)。结论共病抑郁症的T2DM患者血浆nesfatin-1水平较非抑郁症组显著升高,其与T2DM患者的抑郁程度相关,其改变可能在DDM发生发展中发挥一定作用。Objective To research the correlation between nesfatin- 1 and T2 DM complicated with depression. Methods 77 T2 DM patients were recruited. Based on ICD- 10 diagnostic criteria for depression,the patients were divided into depression with DM group（ DDM group,n = 25） and non- depression with DM group（ NDDM group,n = 52）. 30 healthy volunteers were recruited as normal control group（ NC group）. All subjects were assessed with HAMD. Fasting plasma nesfatin- 1,FPG,blood lipid profiles and FINS were detected. The nesfatin- 1 levels were compared among three groups. Results The nesfatin- 1 levels in DDM group were higher than that in NDDM group and NC group（ P〈0. 01）. In all T2 DM patients,nesfatin- 1 was positively correlated with HAMD scores,C- P,and TG levels（ P〈0. 05）. Regression analysis showed that HAMD scores,TG and LDL- C were associated with nesfatin- 1（ P〈0. 05）,nesfatin- 1 was significantly associated with DDM（ OR = 1. 140,P〈0. 01）.Conclusion The nesfatin- 1 level was elevated in T2 DM patients complicated with depression,it was related with the severity of depression. Nesfatin- 1 may partially contribute to the pathogenesis of DDM.

关 键 词：NESFATIN-1 2型糖尿病 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]