长效哌甲酯滴定在儿童注意缺陷多动症并发品行障碍中的应用  

Application of long term and long term methyl ester titration in the children s attention deficit disorder of the complication of ADHD

作　　者：陈群娥[1] 刘建平[1] 窦香君 徐艳[1] 

机构地区：[1]西安市儿童医院,西安710003

出　　处：《国际精神病学杂志》2015年第5期23-26,共4页Journal Of International Psychiatry

摘　　要：目的研究长效哌甲酯片滴定治疗儿童注意缺陷多动障碍(ADHD)合并品行障碍(CD)的效果,观察药物剂量对治疗效果的影响。方法选取2014年1月至2015年1月在本院神经科就诊的儿童注意缺陷多动症并发品行障碍患儿120例,随机分成对照组和试验组各60例,治疗六个月间两组分别接受不同剂量的长效哌甲酯片治疗,在治疗的过程中及实验结束后对试验的结果进行评价。结果 (1)试验组最佳反应发生率明显高于对照组(P<0.05)。(2)试验组在注意多动缺陷障碍筛查量表(SNAP-Ⅳ)中对立违抗、注意力不集中以及冲动多动等多项指标与对照组进行对比,差异具有统计学意义(P<0.05)。(3)在儿童行为量表(CBCL)中,试验组与对照组在交往不良、多动、退缩以及攻击性等六个方面的差异具有统计学的意义(P<0.05)。(4)试验组和对照组副反应发生概率的差异无统计学意义(P>0.05)。结论每天36毫克的长效哌甲酯片对于ADHA相关症状的治疗效果相对比于对照组每天18毫克和54克更为明显,可用于临床用药。Objective Study long- term methylphenidate hydrochloride tablets by dose titration in the treatment of children with attention deficit hyperactivity disorder（ ADHD） with conduct disorder（ CD） and observe the relationship between the clinical efficacy and drug dose. Methods Select January 2014 to 2015 years 1 month in children in our hospital neurology clinic note 120 cases of children with attention- deficit / hyperactivity disorder complicated with conduct disorder,were randomly divided into control group（ 60） and experimental group（ 60）,use different dose of methylphenidate in the treatment,compare the different of the treatment. Results（ 1） The optimal response rate in the experimental group was significantly higher than that in the control group（ P〈0. 05）.（ 2） In the experimental group SNAP- V confrontation defy,attention and hyperactivity impulsivity multiple aspects and control group were compared,the difference has statistical significance（ P〈0. 05）.（ 3） In the CBCL scale,there were significant differences in the six aspects of communication between the experimental group and the control group（ P〈0. 05）.（ 4） There was no significant difference in the incidence of side effects between the experimental group and the control group（ P〉0. 05）. Conclusion Different dosage of long acting methylphenidate tablets for ADHD combined with CD were the effect of the presence of significant differences,36 mg per day of long- term methylphenidate tablets for treatment of ADHD symptoms related to the relative than in the control group.

关 键 词：哌甲酯 滴定 注意缺陷多动症 品行障碍 

分 类 号：R749.94[医药卫生—神经病学与精神病学]