他汀类药物的使用和颅内动脉瘤破裂相关性分析  

Analysis of relativity of statin with rupture of intracranial aneurysm

作　　者：汪林涛[1] 赵平[1] 任永生[2] 潘泰峰[1] 王恒[1] 杨建权[1] 赵斌杰[1] 唐振刚[1] 

机构地区：[1]湖北医药学院附属人民医院神经外科,湖北十堰442000 [2]湖北医药学院生理教研室,湖北十堰442000

出　　处：《中国临床神经外科杂志》2015年第10期614-616,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨他汀类药物对颅内动脉瘤破裂的影响。方法 2010年3月至2014年3月收治颅内囊状动脉瘤67例,其中破裂者32例,未破裂者35例。采用多变量Logistic回归评估他汀类药物的使用和颅内动脉瘤破裂的关系。结果破裂组术前使用他汀类药物4例（12.5%,4/32）,未破裂组16例（45.7%,16/35）。破裂组服用他汀类药物的百分比显著低于未破裂组（P〈0.01）。纠正潜在的混杂干扰后（OR值：0.30,95%可信空间：0.12~0.64）显示,颅内动脉瘤破裂与他汀类药物的使用呈显著负相关,也与高血清总胆固醇浓度有关。结论本结果提示他汀类药物对颅内动脉瘤破裂有一定的预防效果。Objective To explore the effect of statin on the rupture of intracranial aneurysms.MethodsOf 67 patients withintracranial saccate aneurysms treated from March, 2010 to March, 2014, 32 had ruptured intracranial aneurysms and 35 unrupturedintracranial aneurysms. The relationship between statin and the rupture risk of intracranial aneurysm was analyzed by multivariablelogistic regression.ResultsThe percentage（45.7%, 16/35） of the patients who received statin treatment was significantly higher in theunruptured group than that（12.5%, 4/32） in the ruptured group before the surgical treatment（P0.05）. The use of any statin wasnegatively related to the aneurysm rupture after adjustment of potential confounding factors（adjusted odds ratio, 0.42; 95% confidenceinterval, 0.15~0.68）.The rupture of the intracranial aneurysms was also related to the higher serum level of cholesterol.ConclusionItis suggested that statin may prevent the saccate intracranial aneurysms from rupturing.

关 键 词：他汀类药物 颅内动脉瘤 蛛网模下腔出血 

分 类 号：R743.9[医药卫生—神经病学与精神病学]