联苯肼酯微胶囊的制备及性能  

The Preparation and Performance of Bifenazate Microcapsule

作　　者：刘村平 路福绥[2] 廖科超[1] 

机构地区：[1]山东农业大学植物保护学院,山东泰安271018 [2]山东农业大学化学与材料科学学院,山东泰安271018

出　　处：《农药》2015年第10期727-731,共5页Agrochemicals

基　　金：山东省科技发展计划项目(2013GZX20109)

摘　　要：[目的]制备联苯肼酯微胶囊,探究其载药量及包封率、缓释性和光稳定性随组装层数增加的变化规律。[方法]以壳聚糖和羧甲基纤维素钠为壁材,采用层层自组装技术制备联苯肼酯微胶囊,流点法筛选分散稳定剂,紫外分光光度法测定载药量和缓释性能并以此确定组装体系最佳p H值,HPLC法测定联苯肼酯在紫外光下的分解率。[结果]最佳分散稳定剂为SP-3060,组装体系p H值为4。组装层数为12、16、20层的联苯肼酯微胶囊载药量分别为82%、81.6%和78.3%;达到最高释放率所需时间较原药延长了1.6、2.4、2.6倍,在紫外光下的光解率降低了56%、68%和71%。[结论]制备出性能优异的联苯肼酯微胶囊,随着组装层数的增加,获得了不同特性的联苯肼酯微胶囊,其中组装层数为16层的联苯肼酯微胶囊更具有应用价值。[Aims] The aims were to prepare the bifenazate microcapsule and explore the effects of number of assembly layer on drug loading capacity, encapsulation rate, slow-release property and light stability. [Methods] With chitosan and sodium carboxymethyl cellulose as wall materials, the bifenazate microcapsule was prepared by layer-by-layer assembly technology. Flowing point test was used to screen the dispersing agents, and ultraviolet spectrophotometry was used to measure drug loading capacity and slow-release performance so as to choose the best pH. In addition, the photolysis rate under ultraviolet was measured by HPLC. [Results] The best dispersing agent was SP-3060 and the pH of assembly system was 4. When the numbers of assembly layer were 12, 16 and 20, the drug loading capacities were 82, 81.6, 78.3%, the times to reach the highest release-rate were prolonged for 1.6, 2.4, 2.6 times, and the photolysis rates under ultraviolet were decreased to 56, 68, 71%, respectively. [Conclusions] Bifenazate microcapsule with excellent performance was prepared. Different characteristics of bifenazate microcapsules were obtained with the increase of the number of assembly layer, when the number of assembly layer was 16, the bifenazate microcapsule has more practical values.

关 键 词：联苯肼酯 微胶囊 层层自组装 释放 光解 

分 类 号：TQ450.1[化学工程—农药化工]