3,4-二羟基-5-硝基苯甲醛的合成  

Synthesis of 3,4-dihydroxy-5-nitrobenzaldehyde

作　　者：马小双[1] 刘艳军[2] 

机构地区：[1]文山学院环境与资源学院,云南文山663000 [2]解放军第59中心医院疼痛诊疗中心,云南开远661699

出　　处：《广东化工》2015年第20期65-65,共1页Guangdong Chemical Industry

摘　　要：香兰素经常温硝化、脱甲基两步反应制得了恩他卡朋的中间体(3,4-二羟基-5-硝基苯甲醛)。以65%的硝酸对香兰素进行硝化,制得5-硝基香兰素,收率81.2%。用无水三氯化铝和吡啶对5—硝基香兰素进行脱甲基,制得3,4-二羟基-5-硝基苯甲醛,收率96%。总收率78%。The intermediate（3,4-dihydroxy-5-nitrobenzaldehyde） was prepared by using vanillin via two steps, including nitrification, demethylation. The vanillin was nitrified by using 65 % nitric acid to produce 5-nitrovanillin in 81.2 % yield. Next, the 5-nitrovanillin was demethylated by using anhydrous aluminum trichloride and pyridine to give（3,4-dihydroxy-5-nitrobenzaldehyde）, in the yield of 96 %. The total yield is 78 %.

关 键 词：帕金森病 恩他卡朋 香兰素 

分 类 号：TQ[化学工程]