肛门乳头状汗腺瘤临床病理分析  

Clinicopathological analysis of hidradenoma papilliferum of the anus

作　　者：郭一川[1] 郭亚莉[2] 

机构地区：[1]新疆生产建设兵团第一师医院病理科,新疆阿克苏843000 [2]新疆生产建设兵团第一师医院理疗科,新疆阿克苏843000

出　　处：《农垦医学》2015年第2期136-138,共3页Journal of Nongken Medicine

摘　　要：目的:探讨肛门乳头状汗腺瘤的临床特点、病理形态、免疫组化及预后等。方法:收集我科5例肛门乳头状汗腺瘤资料,分析其临床特点,观察病理形态及免疫组化表型,通过随访了解其预后。结果:临床表现患者均为女性,年龄中位数43岁,肿物位于肛门齿状线附近,均行包块切除,随访1年,无复发。病理检查示肿块最大径0.5-1.5cm不等,镜检示瘤组织呈密集的不规则腺管状,部分腺管折叠形成迷路,部分向腔内形成乳头状结构,上皮均由内层分泌性柱状上皮细胞及外层肌上皮细胞构成。病理诊断:肛门乳头状汗腺瘤。免疫表型:5例内层柱状上皮细胞ER、AE1/AE3、CK7阳性,CK20、CEA、Villin阴性,外层肌上皮细胞AE1/AE3、P63阳性。结论:肛门乳头状汗腺瘤非常少见,诊断主要靠常规病理切片确诊,免疫组化标记协助诊断,局部肿物切除为首选,随访1年,无复发,预后较好。Objective： To study and research the clinical pathologic features,immunohistochemistry and prognosis of hidradenoma papilliferum of the anus. Methods：Five cases of hidradenoma papilliferum of the anus were studied to research the clinical pathologic features,immunohistochemistic expression and evaluate the prognosis by follow-up visits.Results：Clinically,patients were all female,the median age was 43,Anus dentate line was the main location. Five cases were all local bag piece resection. Follow-up of one year,no one have recurrence.Pathological examination： the tumors were 0.5 cm to 1.5 cm in diameter. Microscopic examination： Tumor tissue was dense irregular tubulars,Part of the tubulars were folded to form a labyrinth and papillary structure to the cavity formation. Those structures were usually lined with a double layer of the inner epithelial secretory columnar epithelial cells and the outer layer of myoepithelial cells. Pathological diagnosis： Hidradenoma papilliferum of the anus. Immunophenotype：the inner epithelial secretory columnar epithelial cells were positive for ER,AE1/AE3 and CK7,were negative for CK20,CEA and Villin.the myoepithelial cells were positive for AE1/AE3 and P63.Conclusion：Hidradenoma papilliferum of the anus are quite rare.Diagnosis of the tumor relies largely on histopathology.Immunohistochemical markers assist the diagnosis. Local mass resection is preferred. Patients were followed up for 1 years without recurrence and prognosis is good.

关 键 词：肛门 乳头状汗腺瘤 免疫组织化学 

分 类 号：R730.261[医药卫生—肿瘤]