宫颈癌中EMT相关因素的研究进展  

Progression of EMT in the cervical cancer

作　　者：李晨羲 张宗峰[1] 

机构地区：[1]黑龙江省哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《现代肿瘤医学》2015年第21期3204-3207,共4页Journal of Modern Oncology

基　　金：黑龙江省教育厅科研课题(编号:11551163)

摘　　要：宫颈癌的侵袭和转移是导致患者死亡的主要原因。上皮间质转化(epithelial-mesenchymal transition,EMT)使上皮性肿瘤细胞获得间质表型,增强肿瘤细胞的侵袭和转移,在肿瘤发生及进展中发挥重要作用。已有相关研究证实EMT在宫颈癌进展中具有重要作用。本文旨在探讨宫颈癌中EMT的相关因素,为宫颈癌的临床诊断、治疗及预后提供依据。Cervical cancer is one of the most common malignancies in women worldwide ,which main cause of deaths are invasion and metastasis. Epithelial- mesenehymal transition （EMT）can induce epithelial tumor cells to obtain mesenchymal phenotypes, in which it promotes tumor invasion and metastasis. At the same time, it also plays an im- portant role on the development of tumorigenesis. Related researches have shown that EMT has significant influence on the progression of cervical cancer. The purpose of this paper is to explore the factors associated with EMT in cervical cancer, and provide evidences for the clinical diagnosis, treatment and prognosis in cervical cancer.

关 键 词：宫颈癌 EMT 细胞标志物 相关因素 

分 类 号：R737.33[医药卫生—肿瘤]