根尖孔径大小对小型猪牙髓炎组织病理学影响  

Effect of apical sizes on experimentally induced pulpitis in miniature swine

作　　者：樊闪 刘晓勇[3] 汪育苗[3] 王凤光[3] 陈宁宁[1] 郑颖[1] 

机构地区：[1]首都医科大学口腔医学院牙体牙髓科,北京100050 [2]首都医科大学附属北京潞河医院 [3]首都医科大学口腔医学院病理科,北京100050

出　　处：《北京口腔医学》2015年第5期254-258,共5页Beijing Journal of Stomatology

基　　金：国家自然科学基金(81171009)

摘　　要：目的 研究小型猪根尖孔径大小对小型猪实验性牙髓炎组织病理进展的影响,为建立小型猪牙髓炎动物模型选择合适的实验牙。方法 选用18～20月龄的小型猪,体视显微镜下应用Digimizer软件测量小型猪的各组牙齿根尖孔径的大小。使用龈上菌斑诱导法,建立小型猪前牙和前磨牙牙髓炎模型,通过组织病理学观察,分析不同根尖孔径牙髓炎症的特点。结果 18～20月龄小型猪后牙根尖孔径与人牙根尖孔径较为接近;根尖孔较大牙齿的牙髓炎症情况明显轻于根尖孔较小的牙齿。结论 根尖孔径大小对牙髓炎进展有影响,18～20月龄第二、三前磨牙可作为建立小型猪牙髓炎模型较为理想的实验牙。Objective To examine the effect of apical size on experimentally induced pulpitis, and to determine the optimal teeth for establishing experimentally induced pulpitis in miniature swine. Methods Four 18-month-old miniature swine were used in this study. The apical sizes of incisors, canines, premolars and molars were measured using stereoscopy by Digimizer software, respectively. Meanwhile, experimentally induced pulpits models were established by supragingival plaque methods and the characteristics of inflammatory progress were analyzed by histology. Results In 18-20-month-old miniature swine, the premolars had a very comparable size to human permanent molars. Histological studies revealed that apical size had a significant effect on the pathological progress of induced pulpitis. Larger size of apical foramen tended to have localized pulpitis compared to smaller one. Conclusion Apical size has an impact on the pathological progress of pulpitis. In the 18-20-month old miniature swine, the second and third premolars are most suitable for establishing pulpitis models.

关 键 词：根尖孔径 小型猪 牙髓炎 动物模型 病理学 

分 类 号：R781.31[医药卫生—口腔医学]