Nrf2/Keap1/ARE信号通路与难治性呼吸系统疾病研究进展  

Role of Nrf2/Keap1/ARE signaling pathway in respiratory diseases

作　　者：赵萍[1] 高建[2] 

机构地区：[1]安徽医科大学附属巢湖医院,安徽合肥238000 [2]安徽医科大学第一附属医院药学部,国家中医药管理局中药化学三级实验室TCM-2009-202,安徽合肥230022

出　　处：《中国药理学通报》2015年第11期1488-1492,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81274172,81473267,30801535);安徽省卫生厅中医药科研项目(No2012zy53)

摘　　要：Nrf2/Keap1/ARE是重要的抗氧化信号通路,对维持体内抗氧化物与过氧化物平衡有重要作用。氧化应激发生时,Nrf2/Keap1/ARE信号通路被激活,调控下游抗氧化蛋白表达,减轻氧化应激对机体的损伤并减弱氧化应激的程度。近年来的研究发现,Nrf2/Keap1/ARE信号通路与肺纤维化、肺癌、慢性阻塞性肺病等难治性呼吸系统疾病的发生发展有密切联系,该通路可能作为治疗这类疾病的潜在靶点。该文就Nrf2/Keap1/ARE信号通路在难治性呼吸系统疾病中的作用进行综述,进一步了解其在难治性呼吸系统疾病中的作用机制,为这类疾病发病机制和治疗方案的研究提供可靠的参考。Nrf2/Keap1/ARE is an important signaling pathway in maintaining the balance between peroxide and antioxidants. Once oxidative stress happened, Nrf2/Keap1/ARE would be ac-tivated to regulate the expression of downstream antioxidant pro-teins that could reduce the injury from oxidative stress and the level of oxidative stress. Recent researches show that Nrf2/Keap1/ARE signaling pathway is closely related to refractory re-spiratory diseases such as pulmonary fibrosis (PF), lung canc-er, chronic obstructive pulmonary disease (COPD), suggesting that Nrf2/Keap1/ARE signaling pathway may be a potential ther-apeutic target. This review focuses on the role of Nrf2/Keap1/ARE signaling pathway in refractory respiratory diseases in order to further understand the related mechanism and provide evidence for the diagnosis and treatment of refractory respiratory diseases.

关 键 词：难治性呼吸系统疾病 氧化应激 Nrf2/Keap1/ARE信号通路 肺纤维化 肺癌 慢性阻塞性肺病 急性肺损伤 支气管哮喘 

分 类 号：R-05[医药卫生] R349.1