外侧缰核功能及相关机制研究进展  

Progress on functions of lateral habenula and related mechanisms

作　　者：姚瑞[1,2] 曹君利[1,2,3] 

机构地区：[1]江苏省麻醉学重点实验室 [2]江苏省麻醉与镇痛应用技术重点实验室,江苏徐州221004 [3]徐州医学院附属医院麻醉科,江苏徐州221002

出　　处：《中国药理学通报》2015年第11期1502-1505,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金重点项目(No 81230025);国家自然科学基金面上项目(No 81070888)

摘　　要：外侧缰核(lateral habenula,LHb)是缰核的组成部分,位于上丘脑。其不仅是边缘前脑和中脑之间传递信息的主要中继站,能控制中脑奖赏途径,介导边缘前脑富含多巴胺的脑区和中脑边缘结构中多巴胺神经元的负反馈信息的传递,而且与5-HT系统等联系紧密。近年来研究发现LHb参与了多种生理活动,从而影响机体的功能,如药物成瘾、奖赏—厌恶、疼痛、睡眠和抑郁症的发生等。该文就LHb参与上述生理过程及相关机制进行综述。Lateral habenula ( LHb ) , which is situated in the dorsal diencephalon of all vertebrates, is an important component of the habenular complex. The neural network outlined in previ-ous studies indicates that LHb acts not only as an important relay station to link the forebrain with the midbrain regions that in-volved in regulating behavioral responses to reward and mediating the transmassion of negative feedback information, but also is closely connected with 5-HT system. Indeed, recently studies demonstrate that experimental manipulations of LHb are followed by behavioural alterations in relation to drug addiction, reward-a-version responses, pain, sleep, depression and so on. This arti-cle mainly reviews the mechanisms of LHb involved in all kinds of physiological activities.

关 键 词：外侧缰核 药物成瘾 逃跑回避反应 奖赏-厌恶 抑郁症 疼痛 认知功能与情绪 

分 类 号：R-05[医药卫生] R322.81