BEP与CBV化疗方案联合自体干细胞移植治疗复发性淋巴瘤的疗效和毒性比较  

Comparison of the Efficacy and Toxicity of Different Chemotherapies Combined with Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Relapsing Malignant Lymphoma

作　　者：林聪猛[1] 沈绿瑛[1] 唐海涛[2] 尹俊杰[2] 

机构地区：[1]福建医科大学附属漳州市医院血液科,福建漳州363000 [2]厦门大学附属东南医院血液科,福建漳州363000

出　　处：《肿瘤药学》2015年第5期362-367,共6页Anti-Tumor Pharmacy

摘　　要：目的：比较BEP与CBV化疗方案结合自体干细胞移植治疗恶性淋巴瘤的临床疗效和毒性。方法回顾性分析在我市两家三甲医院血液科治疗并经自体干细胞移植的177例复发性淋巴瘤患者的临床资料，其中89例患者采用BEP方案（BEP组），88例患者采用CBV方案（CBV组）。观察和比较两组患者的中性粒细胞与血小板移植的平均时间、4年总生存率（OS）与无进展生存率（PFS）、住院时间及毒性反应的发生情况。结果随访时间40.8（1-60）个月，移植后CBV组血小板数大于50＆#215;109 L-1的患者比例显著高于BEP组（P=0.045）。移植后，BEP组与CBV组患者的缓解率（98.9%vs.97.7%,P=0.083）、4年OS（80.9％ vs.72.7％，P=0.755）、PFS （73.0％ vs.63.6％，P=0.668）与住院时间（13（10-24）vs.13（10-42），P=0.655）比较均无显著差异。BEP组感染性并发症的发生率显著高于CBV组（P=0.01）。结论 BEP预处理方案对AHSCT患者的疗效与使用CBV方案相当，BEP方案可导致患者更高的感染性并发症发生率。Objective To compare the efficacy and toxicity of BEP and CBV chemotherapy combined with autolo-gous hematopoietic stem cell transplantation （AHSCT） in the treatment of relapsing malignant lymphoma. Methods We retrospectively analyzed the clinical data of 177 recurrent lymphoma patients. They all had the treatment of autologous hematopoietic stem cell transplantation. 89 of them were treated with BEP chemotherapy （BEP group）, and another 88 pa-tients were treated with CBV chemotherapy （CBV group）. We observed and compared the average time for neutrophil and platelet transplants, 4-year rates of overall survival （OS） and progression-free survival （PFS）, hospital stays, toxic reaction between the two groups. Results The follow-up was 40.8 （1-60） months. The proportion of patients whose platelet counts were greater than 50x109 L-1 in CBV group was significantly higher than the proportion in BEP group after transplanta-tion （P=0.045）. After transplantation, there were no significant difference between BEP group and CBV group in complete remissionrate（98.9%vs.97.7%,P=0.083）,4-yearratesofOS（80.9%vs.72.7%,P=0.755）,PFS（73.0% vs.63.6%, P=0.668）, hospital stays （13（10-24） v s . 13（10-42）, P=0.655）. The infectious complications rate of BEP group was sig-nificantly higher than CBV group （P=0.01）. Conclusion BEP regimen had comparable short-and long-term outcomes with CBV regimen for AHSCT. BEP regimen may result in a higher incidence rate of infectious complications.

关 键 词：复发性淋巴瘤 化疗 自体干细胞移植 毒性 疗效 

分 类 号：R733.4[医药卫生—肿瘤]