Discovery of New Peptide Drugs for Neuroprotection  

出　　处：《中国药理学通报》2015年第B11期266-267,共2页Chinese Pharmacological Bulletin

摘　　要：Adult central neurons in some invertebrates can regenerate their axons and form synaptic connects follow- ing injury. Thus, identifying molecules that enable axonal regeneration may suggest new directions to stimulate ax- onal re-growth in the CNS in vertebrates, which typically do not regenerate. In this talk, I will discuss the newly i-dentified pro-regenerative molecules from freshwater pond snail, Lymnaea stagnalis, and our first evidence that the snail molecule and its fragments promote the outgrowth capacity and prevent cell death of mammalian neurons. Our findings provide a potential alternative approach to identify new molecular mechanisms underlying neuroprotection following injury.

关 键 词：神经保护作用 多肽药物 无脊椎动物 中枢神经元 分子机制 再生轴突 中枢神经系统 生长能力 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R977.6[医药卫生—临床医学]