功能性消化不良与胃黏膜肥大细胞、血浆胃动素的关系  

Relationship of Functional Dyspepsia with Gastric Mucosal Mast Cells and Plasma Motilin

作　　者：陈海山[1] 龚锦容[1] 黄朝忠[1] 林志辉[2] 

机构地区：[1]福建省莆田市莆田学院附属医院消化科,351100 [2]福建医科大学附属省立医院消化科

出　　处：《胃肠病学》2015年第9期533-537,共5页Chinese Journal of Gastroenterology

摘　　要：背景:功能性消化不良(FD)是常见的功能性疾病,严重影响了患者的生活质量和身心健康,已越来越引起临床医师的关注。目的:探讨肥大细胞(MC)、胃动素(MTL)在FD发病中的作用。方法:选取2013年9月-2014年1月莆田学院附属医院的60例FD患者,其中餐后不适综合征(PDS)32例,上腹痛综合征(EPS)28例,以28名健康志愿者作为对照组(HS组)。比较胃黏膜MC计数、血浆MTL水平(空腹和饮温水后)以及胃排空时间(T1/2)。结果:与HS组相比,FD组胃黏膜MC计数显著增多(P<0.001),空腹和饮温水后血浆MTL水平均显著降低(P<0.001),T1/2显著延长(P<0.001)。PDS亚组MC计数与EPS亚组无明显差异(P=0.094),空腹和饮温水后血浆MTL水平显著低于EPS亚组(P<0.001),T1/2显著延长(P<0.001)。结论:FD患者胃黏膜MC计数较HS组显著增多,提示MC可能在FD的发病中起一定作用。FD患者血浆MTL水平下降,可能是FD发病和产生相应症状的原因之一。Background： Functional dyspepsia（ FD） is a commonly seen functional disease which has great impact on patient＇s quality of life and mental health,and has got more and more concern by clinicians. Aims： To explore the role of mast cells（ MC） and plasma motilin（ MTL） in the pathogenesis of FD. Methods： Sixty FD patients including 32 postprandial distress syndrome（ PDS） and 28 epigastric pain syndrome（ EPS） patients from September 2013 to January 2014 at the Affiliated Hospital of Putian University were enrolled,and 28 healthy volunteers were served as controls（ HS group）. The number of gastric mucosal MC,plasma MTL level（ fasting and 30 minutes after drinking warm water） and gastric emptying time（ T1 /2） were compared. Results： Compared with HS group,number of gastric mucosal MC was significantly increased（ P〈0. 001）,plasma MTL level before and after drinking warm water in FD group were significantly decreased（ P〈0. 001）,T1 /2was significantly prolonged（ P〈0. 001）. No significant difference in number of MC was found between PDS subgroup and EPS subgroup（ P = 0. 094）. Plasma MTL level before and after drinking warm water in PDS subgroup were significantly lower than those in EPS subgroup（ P〈0. 001）,and T1 /2was significantly prolonged（ P〈0. 001）.Conclusions： Number of gastric mucosal MC is significantly increased in FD patients compared with HS group,suggesting MC may play a role in the pathogenesis of FD. Plasma MTL level is decreased in FD patients,which may be one of the factors involved in the pathogenesis and occurrence of corresponding symptoms of FD.

关 键 词：功能性消化不良 肥大细胞 促胃动素 胃排空 

分 类 号：R57[医药卫生—消化系统]