热休克蛋白70与胃癌相关性的研究进展  

Advances in Study on Relationship between Heat Shock Protein 70 and Gastric Cancer

作　　者：鲁旭阳 陈茁 王俊雄 罗大蓓 金醒昉 

机构地区：[1]昆明市延安医院消化科,650000

出　　处：《胃肠病学》2015年第9期567-570,共4页Chinese Journal of Gastroenterology

基　　金：云南省科技计划项目(2013FZ228)

摘　　要：胃癌是消化系统常见的恶性肿瘤,发病率和死亡率分别占全球肿瘤的第4位和第2位。胃癌的发生由遗传、环境等诸多因素相互作用所致,是一个多因素、多步骤参与的癌变过程。热休克蛋白(HSP)70是HSP家族中最重要的一类具有分子伴侣作用的蛋白,参与机体特异性免疫和固有免疫。研究表明HSP70与胃癌的发生、发展密切相关。本文就HSP70与胃癌相关性的研究进展作一综述。Gastric cancer is one of the most commonly seen malignant tumors,and is the fourth leading cause of morbidity and second leading cause of mortality among malignancies worldwide. The genesis of gastric cancer is the result of interaction between genetic and environmental factors,and is a multi-factor and multi-step carcinogenesis. As one of the most important members in the heat shock protein（ HSP） family,HSP70 plays a molecular chaperone role,and is involved in body specific immunity and innate immunity. Studies have demonstrated that over expression of HSP70 often correlates with the genesis and development of gastric cancer. This article reviewed the advances in study on relationship between HSP70 and gastric cancer.

关 键 词：胃肿瘤 HSP70热休克蛋白质类 基因多态性 治疗 

分 类 号：R735.2[医药卫生—肿瘤]