细胞凋亡在体外循环肺损伤中的研究进展  

Role of cell apoptosis in cardiopulmonary bypass related lung injury

作　　者：何苗[1] 张红[1] 

机构地区：[1]遵义医学院贵州省麻醉与器官保护基础研究重点实验室,遵义医学硕士研究生563000

出　　处：《医学研究生学报》2015年第10期1102-1106,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81460074)

摘　　要：体外循环(cardiopulmonary bypass,CPB)相关性肺损伤是心脏手术最常见的并发症,多数学者认为缺血再灌注损伤及全身炎症反应可能是CPB肺损伤发生的重要原因,但其具体机制尚有待阐明。近年来,细胞凋亡在此发病机制中日益受到重视,从凋亡的角度探寻CPB相关性肺损伤成为研究热点。文中主要就CPB肺组织细胞凋亡发生的特点、原因及其分子调控机制的最新研究展开综述。Cardiopulmonary bypass（ CPB） related lung injury is the most common complication in cardiac surgery. Ischemia reperfusion injury and systemic inflammatory reaction may be the important causes of CPB-related lung injury,but the specific mechanism is still to be elucidated. In recent years,apoptosis is paid increasing attention in the pathogenesis of CPB. Therefore,cell apoptosis has been a hot spot in the research of CPB related lung injury. This article summarizes the latest researches on the characteristics,reasons and mechanisms of CPB-related pneumonocyte apoptosis.

关 键 词：细胞凋亡 体外循环 肺损伤 分子调控机制 

分 类 号：R363[医药卫生—病理学]