ABO血型与胃癌患者预后关系的研究  

Study on prognosis relationship between ABO blood groups of patients with gastric cancer

作　　者：肖书傲 丰帆[1] 孙力[1] 徐光辉[1] 连肖[1] 郭曼[1] 柰超[1] 刘震[1] 刘书尚 张磊[1] 蔡磊[1] 柳金强 张洪伟[1] 

机构地区：[1]第四军医大学附属西京医院消化一科,西安710032

出　　处：《中华胃肠外科杂志》2015年第10期1011-1015,共5页Chinese Journal of Gastrointestinal Surgery

基　　金：国家自然科学基金（31100643）;第四军医大学西京医院助推计划（XJZT12203）

摘　　要：目的探讨ABO血型与胃癌患者预后的关系。方法回顾性分析2008年6月至2013年10月间西京医院消化外科诊断为胃癌并接受根治性手术治疗的2838例患者的临床及随访资料。比较不同临床病理特征下ABO血型（A、B、O及AB型）的分布情况，并比较不同ABO血型患者的5年总体生存率。结果ABO血型与胃癌患者的临床病理特征无显著关联（均P〉0．05）。A、B、O和AB血型患者的5年总体生存率分别为57.3％、54．7％、57．4％和53．5％，差异亦无统计学意义（P=0．772）。但在Ⅲ期和有吸烟史的亚组中，AB血型患者5年总体生存率均明显高于非AB血型者（Ⅲ期：44．7％比25．2％，P=0．014；吸烟史：74．9％比53．4％，P=0．044）。结论ABO血型与胃癌患者的临床病理特征及预后均无明显关联；但对于Ⅲ期患者以及有吸烟史的患者，AB血型可提示相对更好的预后。Objective To investigate the relationship of ABO blood group with the clinicopathological characteristics in patients with gastric cancer and to assess whether the ABO blood group was associated with prognosis. Method Clinicopathological and follow-up data of 2838 patients with gastric cancer who underwent radical gastrectomy in our department from June 2008 to October 2013 were analyzed retrospectively. The distribution of ABO blood group under different clinicopathological characteristics and the overall 5-year survival of ABO blood group were compared. Results There were no significant differences in clinicopathological characteristics among patients with different ABO blood groups （all P〉0.05）. The 5-year overall survival（OS） rates were 57.3% for patients with blood type A, 54.7% for type B, 57.4% for type O, and 53.5% for type AB. Though there was no significance difference of survival among ABO blood groups （P=0.722）, while the subgroup analysis indicated that stage m patients of blood group Non-AB had a poorer OS compared to those of blood group AB （25.2% vs. 44.7%, P=0.014）; smoking patients of blood group Non-AB had a poorer OS compared to those of blood group AB （53.4% vs. 74.9% , P=0.044）. Conclusion Neither clinicopathological characteristics nor overall survival are associated with the ABO blood group, however, stage lU and smoking patients of blood group Non-AB have a poorer OS compared to those of blood group AB.

关 键 词：胃肿瘤 ABO血型 临床病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]