女性高危型人乳头瘤病毒感染2501例调查  

Epidemiological survey of high-risk human papillomavirus among 2501 woman

作　　者：陈静娜[1] 陈丽丹[1] 张卫云[1] 杨永泉[1] 唐荣芝[1] 孙朝晖[1] 李林海[1] 

机构地区：[1]广州军区广州总医院检验科,广东广州510010

出　　处：《南方医科大学学报》2015年第10期1487-1491,共5页Journal of Southern Medical University

基　　金：广州市健康医疗协同创新重大专项(201400000004-1)

摘　　要：目的了解广州地区2013年和2014年女性高危型HPV感染情况,对该地区宫颈癌的预防和疫苗的开发提供指导。方法采用荧光PCR分型定性检测方法,对2501例来院就诊的女性患者或体检者宫颈分泌物中的13种高危型HPV特异性DNA核酸片段进行检测。结果 2013年和2014年高危型HPV总感染率分别为14.85%(146/983)、14.56%(221/1518),差异无统计学意义(χ2=0.041,P=0.839)。各年内各年龄段感染率差异亦无统计学意义(χ2=2.916,P=0.572;χ2=6.494,P=0.165)。2013年和2014年HPV亚型的总体构成比差异无统计学意义(χ2=11.872,P=0.452),2013年各亚型感染频次构成比从高到低依次为HPV52、16、58、56、39、51、68、59、31、35、18、33、45型,而2014年为HPV52、16、58、68、18、51、56、39、31、33、59、35、45型。结论广州地区女性高危型HPV感染率较高,各年龄段女性均应定期进行高危型HPV筛查,以预防和早期发现宫颈癌。开发新的多价疫苗或通用疫苗预防HPV感染,从而降低宫颈癌的发病率。Objective To survey the prevalence of high-risk human papillomavirus（HPV） in woman in Guangzhou during the period from 2013 to 2014. Methods A total of 2501 women in Guangzhou seeking medical attention in our hospital underwent high-risk HPV genotype screening of cervical specimens using real-time PCR. Results The prevalence of high-risk HPV infection among the women was 14.85%（146/983） in the year 2013, similar to the rate of 14.56%（221/1518） in 2014（χ^2=0.041, P=0.839）; no significant differences were found in the high-risk HPV infection rates between different age groups in either2013（χ^2=2.916, P=0.572） or 2014（χ^2=6.494, P=0.165）. The constituent ratio of the 13 types of high-risk HPV showed no significant difference between 2013 and 2014（χ^2=11.872, P=0.452）. The 13 HPV genotypes detected, listed in a descending order of the constituent ratios, included HPV-52,-16,-58,-56,-39,-51,-68,-59,-31,-35,-18,-33 and-45 in 2013, and were HPV-52,-16,-58,-68,-18,-51,-56,-39,-31,-33,-59,-35 and-45 in 2014. Conclusion We report a high prevalence of high-risk HPV among women in Guangzhou, which suggests the necessity of screening for high-risk HPV-DNA among women at all ages for prevention and early detection of cervical cancer.

关 键 词：高危型HPV 广州地区 流行病学 

分 类 号：R737.33[医药卫生—肿瘤]