血浆甘油三酯及胆固醇水平与乳腺癌的相关性探讨  

The relationship between plasma triglycerides, cholesterol levels and breast cancer

作　　者：高忠诚[1] 张小霞[1] 罗坤[2] 于理想[3] 余之刚[3] 李波[4] 

机构地区：[1]临沂市人民医院两腺外科,山东276003 [2]山东大学医学院临床医学五年制,250012 [3]山东大学第二医院乳腺外科,250033 [4]北京医院乳腺中心,100730

出　　处：《中华内分泌外科杂志》2015年第5期381-384,共4页Chinese Journal of Endocrine Surgery

基　　金：山东省自然科学基金重点项目（ZR2014HZ004）

摘　　要：目的：探讨血浆甘油三酯（ triglycerides ，TG）及胆固醇（ cholesterol ，TC）水平与乳腺癌的相关性。方法收集2014年5月至2014年10月于临沂市人民医院就诊的女性乳腺癌105例（22～69岁），健康体检者261例（16～52岁），所有入组者均采集空腹静脉血，检测TG及TC水平，分别比较年龄＜35岁、35～45岁及≥45岁乳腺癌组与同年龄段健康对照组TG、TC水平差异，同法比较体重指数（ body mass in-dex，BMI）＜18.5、18.5～24及≥24乳腺癌组与同BMI水平健康对照组TG、TC水平差异。结果乳腺癌组TG水平高于健康对照组（t＝－3.97，P＝0.00），TC水平低于健康对照组（t＝2.49，P＝0.01）；≥45岁的乳腺癌患者组TG水平高于同年龄段的健康对照组（t＝－4.31，P＝0.00），＜35岁及35～45岁乳腺癌组TC水平低于同年龄组的健康对照组（t＝3.12，P＝0.00及t＝2.41，P＝0.02）；各BMI分组（＜18.5、18.5～24.0、≥24）乳腺癌组TG水平均低于健康对照组（t＝－3.67，P＝0.01；t＝－3.87，P＝0.00及t＝－2.01，P＝0.04），BMI＜18.5乳腺癌组TC水平高于同BMI水平的健康对照组（t＝－3.41，P＝0.01）， BMI≥24乳腺癌组TC水平低于同BMI水平的健康对照组（t＝3.53，P＝0.01）。结论不同年龄段TG及TC水平与乳腺癌相关性存在差异，年龄≥45岁的乳腺癌患者与同年龄段健康对照相比具有较高的TG水平，＜45岁的乳腺癌患者与同年龄段健康对照相比具有较低的TC水平。Objective To investigate the relationship between plasma triglycerides （ TG ） , cholesterol （TC）levels and breast cancer.Methods 105 cases of breast cancer（age from 22 to 69 years）and 261 cases of healthy control（age from 16 to 52 years）admitted from May.2014 to Oct.2014 were studied.TG and TC were tested.Subgroup analysis was performed by age （〈35, 35-45, ≥45 years） and BMI（ 〈18.5, 18.5-24, ≥24）.Results TG level in breast cancer group was significantly higher than that of the healthy control group （t=-3.97,P=0.00）, and TC level was lower than that in the healthy control group （t=2.49, P=0.01）.TG lev-el of breast cancer patients≥45 years old was higher than that in the healthy control group （ t=-4.31, P=0.00）.TC level of breast cancer patients 〈35 years and from 35 to 45 years was lower than that of the healthy control group（t=3.12, P=0.00及t=2.41, P=0.02）; TG levels in breast cancer group were significantly lower than those of the healthy control group for all BMI subgroup （ t=-3.67, P=0.01 for BMI〈18.5; t=-3.87, P=0.00 for BMI from 18.5 to 24.0;t=-2.01, P=0.04 for BMI≥24）.TC level of breast cancer patients was higher than that of the healthy control group for patients whose BMI 〈18.5（t=-3.41, P=0.01） and it was lower than that of the healthy control group for patients whose BMI≥24.Conclusions The relation-ship between TG , TC and breast cancer is associated with age .Compared with healthy group , breast cancer pa-tients≥45 years have a higher TG level and breast cancer patients 〈45 years have a lower TC level .

关 键 词：乳腺癌 甘油三酯 胆固醇 

分 类 号：R737.9[医药卫生—肿瘤]