转录因子DEC1在肿瘤发生发展过程中的作用  

Role of transcription factor DEC1 in the initiation and progression of malignant tumors

作　　者：杨欢[1] 熊晶[2] 洛文靖 奚涛[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009 [2]南京医科大学基础医学院药理学系,南京210029

出　　处：《中国药科大学学报》2015年第5期541-547,共7页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81302855);江苏省自然科学基金资助项目(No.BK2012446)~~

摘　　要：转录因子DEC1属于bHLH家族,与肿瘤细胞增殖分化、淋巴细胞成熟、生物节律调节、免疫应答以及应激反应密切相关。近期研究表明,多种肿瘤组织和肿瘤细胞中DEC1异常高表达,且肿瘤组织中DEC1的表达与肿瘤分级相关。本文重点介绍DEC1与肿瘤细胞增殖、凋亡、衰老以及侵袭转移等表型之间的关系,从而进一步阐释DEC1在肿瘤发生发展中的作用。DEC1 is a basic helix-loop-helix（bHLH）transcription factor involved in the regulation of cell prolif-eration;cell differentiation;lymphocytes maturation;circadian rhythms;immune response and response to hypoxia.Recent studies have revealed that the expression of DEC1 is abnormally high in various tumor tissues and cells.In addition;the expression of DEC1 in the tumor tissue is related to the malignancy of various cancer types.This paper;therefore;focuses on the relationship between DEC1 and proliferation;apoptosis;cellular senes-cence;invasion and metastasis of tumor cells;in order to elaborate the role of DEC1 in the pathogenesis and pro-gression of tumor.

关 键 词：转录因子 DEC1 增殖 凋亡 侵袭转移 细胞衰老 

分 类 号：R730.2[医药卫生—肿瘤]