基于柱弥散光源体内辐照的前列腺扫描光声成像仿体实验  

Phantom experimental photoacoustic scanning imaging of prostate based on internal light irradiation using cylindrical diffusing source

作　　者：彭东青[1,2] 谢文明[3] 吴淑莲[1] 唐嘉铭 李志芳[1] 李晖[1] 

机构地区：[1]福建师范大学光电与信息工程学院,医学光电科学教育部重点实验室,光子技术福建省重点实验室,福州350007 [2]集美大学理学院,厦门361021 [3]福建工程学院信息科学与工程学院,福州350118

出　　处：《物理学报》2015年第20期372-378,共7页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:61178089,81201124);福建省科技计划重点项目(批准号:2011Y0019);福建省教育厅科技计划(批准号:JA14189)资助的课题~~

摘　　要：光声成像技术是一种非常有前景的前列腺早期检测与成像的新技术.在现有前列腺光声成像技术中,通常采用的腺体外光源辐照方式由于受外围组织的影响,容易减弱深部前列腺组织的光能量吸收,导致辐照范围减小,引起光声成像深度不足,难以实现无损前列腺癌的检测.本文基于前列腺组织的结构特征,依据一种以柱状弥散光纤在尿道对前列腺实施光辐照、并利用外置于直肠内的长焦区聚焦式超声换能器检测光声信号的前列腺光声扫描成像技术,构建了光声成像实验系统,开展了仿体实验.测试结果表明,系统能够实现样品中吸收体的定位和成像,结合柱弥散光源体内辐照可使成像深度提高,同时侧向成像范围也较大.初步结果表明,借助柱弥散光源进行体内光辐照的光声信号新激发方式结合长焦区超声探头在前列腺癌早期无创诊断上具有潜在的应用前景.Photoacoustic imaging has recently emerged as a promising imaging modality for prostate cancer.As a usual light illumination model in the previous studies,the external light illumination is difficult to obtain an accurate reconstructed photoacoustic image.It suffers a great deal of light absorption attenuation by the surrounding scattering tissue and cannot colletct sufficient ultrasound signals for image reconstruction.Some particular methods are required to be considered in the photoacoustic imaging technique for examining prostate,such as a light delivery to prostate with sufficient penetrating depth and minimal invasiveness.According to the structural characteristic of prostate tissue,a photoacoustic imaging system is built by using a novel technique for prostate in this paper.In our photoacoustic imaging system,a cylindrical diffusing source with a 2-cm-long diffuser tip is used for an internal light irradiation through a urethra,and a focused transducer with a 3.5 MHz central frequency and 30.3 mm extended focal zone is located in the rectum for scanning the photoacoustic signal.Phantom experimental imaging is carried out.In the experiment,a transverse resolution of2.21 mm and an axial resolution of 0.39 mm are obtained.The results demonstrate that the system could achieve the accurate imaging position of the absorber in the tissue sample.Because of the symmetrical emitting of the cylindrical diffusing light source and a relatively better lateral uniformity of light absorption around the light source through the internal irradiation model via urethra,light absorption of the upper side of the light source is almost the same as that of the lower side.Therefore the lengthways and lateral imaging ranges can be improved.In addition,the laser energy is allowed to be increased appropriately to obtain a further imaging result without worrying about heat damages to normal tissues,for the light absorption is less around the cylindrical diffusing light source.In conclusion,the preliminary studies show that the new tec

关 键 词：医用光学技术 弥散光源 前列腺 光声成像 

分 类 号：R737.25[医药卫生—肿瘤] TP391.41[医药卫生—临床医学]