伴轻度认知障碍的正常眼压性青光眼多导睡眠图分析  

Analysis of polysomnography of normal tension glaucoma patients with mild cognitive impairment

作　　者：刘洁琼[1,2] 王丽平[1] 沈扬[1] 冬雪川[3] 张纯[3] 古雅兰[4] 杜晨[4] 宋昱[4] 

机构地区：[1]北京大学第三医院神经内科,北京100191 [2]河北省沧州市中心医院神经内三科 [3]北京大学第三医院眼科 [4]北京大学第三医院耳鼻喉科

出　　处：《中国神经精神疾病杂志》2015年第9期536-541,共6页Chinese Journal of Nervous and Mental Diseases

摘　　要：目的探讨伴轻度认知障碍(mild cognitive impairment,MCI)的正常眼压性青光眼(normal tension glaucoma,NTG)患者多导睡眠图的特点。方法本研究对35例经北京大学第三医院眼科确诊为NTG的患者,均进行神经心理量表测评、匹兹堡睡眠质量指数(Pittsburgh slrrp quality index,PSQI)和多导睡眠图(polysomnography,PSG)检查,其中伴MCI者16例(伴MCI组),不伴MCI者19例(不伴MCI组)。结果 PSQI显示伴MCI组中有睡眠障碍者占43.8%(7/16例),其PSQI总分高于不伴MCI组,差异有统计学意义(P<0.05)。不伴MCI组患者睡眠效率正常,且优于伴MCI组,差异有统计学意义(P<0.05)。PSG显示伴MCI组患者87.5%(14/16)存在PSG睡眠结构紊乱。伴MCI组较不伴MCI组NREM期N3期睡眠时间明显缩短,差异有统计学意义(P<0.05)。结论伴MCI组NTG患者更易出现睡眠障碍,睡眠结构紊乱、尤其是NREM期N3期睡眠时间的缩短与NTG患者认知功能下降有关。ObjectiveTo assess the characteristic of normal tension glaucoma（NTG） patients with mild cognitive impairment（MCI）.MethodsThis study included twenty-six cases of normal tension glaucoma patients who were diagnosed at ophthalmology department of Peking University Third Hospital. All the participants were examined by using the scales of Montreal Cognitive Assessment（Mo CA）, mini-mental state examination（MMSE）, clinical dementia rating（CDR）, activities of daily living（ADL）, Hamilton anxiety scale（HAMA）, Hamilton depression scale（HAMD）, Pittsburgh Sleep Quality Index（PSQI） and polysomnography（PSG）. The patients were then divided into Group with MCI（16cases） and Group without MCI（19 cases）.ResultsThere was no difference between the two groups in gender, age, education, depression, anxiety and body mass index（BMI）（P〈0.05）, but significant difference in Mo CA scores（P〈0.05）.The incidence rate of sleep disorder of PSQI in was 28.6%（10/35 patients） of total NTG patients, 43.8%（7/16 patients）in Group with MCI, and 15.8%（3/19 patients） in Group without MCI, respectively. The PSQI score was higher in Group with MCI than in Group without MCI（P〈0.05）. Sleep efficiency was higher in Group without MCI than in Groupwith MCI（P〈0.05）, but no difference was found between the two groups in six other indexes of PSQI（P〈0.05）. The incidence rate of sleep structure disorder of PSG in all the NTG patients was 85.7%（30/35 patients）, 87.5%（14/16 patients） in Group with MCI, and 84.2%（16/19 patients） in Group without MCI. Sleep time of NREM-N3 was significantly shorter in Group with MCI than in Group without MCI（P〈0.05）, but no difference was found between those groups in total sleep time, sleep efficiency, sleep latency and REM time（P〈0.05）.ConclusionNTG patients with mild cognitive impairment are more prone to sleep disorders, especially sleep structure disturbance and short NREM-N3 time may affect cognitive function.

关 键 词：正常眼压性青光眼 轻度认知障碍 阿尔茨海默病 多导睡眠图 

分 类 号：R775[医药卫生—眼科] R749.1[医药卫生—临床医学]