不同药物治疗急性胆绞痛的效果及安全性比较  

Evaluation of clinical efficacy of different medications for acute biliary colic

作　　者：魏路佳 

机构地区：[1]北京市安贞医院急诊科,北京100029

出　　处：《临床肝胆病杂志》2015年第10期1615-1617,共3页Journal of Clinical Hepatology

摘　　要：目的探讨几种不同药物治疗急性胆绞痛的临床效果。方法回顾性分析北京市安贞医院2012年1月-2014年1月收治的急性胆绞痛患者240例,根据不同用药分为4组,即盐酸消旋山莨菪碱组(A组)、间苯三酚组(B组)、盐酸曲马多组(C组)、地佐辛组(D组),每组60例。分别对4组之间视觉模拟评分(VAS)、临床疗效以及不良反应等方面进行比较。计量资料组间比较采用方差分析,计数资料组间比较采用χ2检验。结果给药后,各组VAS评分较给药前均明显降低(P<0.01),其中D组显著低于A、B组(P值均<0.01);在疼痛缓解时间方面,A组时间最长,D组时间最短,差异有统计学意义(P<0.05);在临床疗效方面,D组总有效率最高,A组总有效率最低,差异有统计学意义(P<0.05);在不良反应情况方面,C、D组总不良反应率均最低,A组最高,C、D组与A组比较,差异均有统计学意义(P值均<0.01)。结论地佐辛与盐酸曲马多治疗急性胆绞痛总体效果较消旋山莨菪碱和间苯三酚好,值得临床上进一步推广。Objective To explore the clinical efficacy of several medications for acute biliary colic. Methods Two hundred and forty patients with acute biliary colic admitted to Beijing Anzhen Hospital from January 2012 to January 2014 were selected for retrospective analysis and randomly divided into four groups,namely raceanisodamine hydrochloride group（ group A）,phloroglucinol group（ group B）,tramadol hydrochloride（ group C）,and dezocine group（ group D）,with 60 cases in each group. The Visual Analogue Scale（ VAS） score,clinical efficacy,and adverse reactions were compared between the four groups using analysis of variance for continuous data and chi- square test for categorical data. Results VAS scores were decreased significantly after the treatment in each group（ P〈0. 01） and the score in group D was the lowest（ P〈0. 01）. In terms of time to pain relief,the time in group A was the longest,and that in group D was the shortest,with significant difference（ P〈0. 05）. As for clinical efficacy,the overall response rate in group D was the highest,while that in group A was the lowest,with significant difference（ P〈0. 05）. The incidence of adverse reactions in groups C and D was the lowest,while that in group A was the highest,with significant difference（ P〈0. 01）. Conclusion The clinical efficacy of dezocine and tramadol hydrochloride is better than that of raceanisodamine hydrochloride and phloroglucinol,and the former two are worthy of further clinical application.

关 键 词：胆道疾病 绞痛 药物疗法 山莨菪碱 间苯三酚 曲马多 地佐辛 

分 类 号：R575.6[医药卫生—消化系统]