启东地区2006-2014年高考生血清HBsAg携带状况分析  

HBs Ag seroprevalence in students for college entrance examination from 2006 to 2014 in Qidong of Jiangsu Province

作　　者：倪正平[1] 陈陶阳[1] 沈蓉[1] 陆玲玲[1] 薛学峰[1] 黄飞[1] 施平凡[1] 

机构地区：[1]江苏省启东市人民医院启东肝癌防治研究所,江苏启东226200

出　　处：《临床肝胆病杂志》2015年第10期1692-1694,共3页Journal of Clinical Hepatology

摘　　要：目的了解启东青年一代血清HBs Ag携带状况。方法随机选择启东市内三所中学2006-2014年连续9届高三学生(高考组),共15 534人,其中有部分学生在出生时接种过乙型肝炎疫苗。选择来自2007-2013年在本院体检的健康人群(成人组),共1208人,被确认未在出生时接种过乙型肝炎疫苗。两组对象以ELISA法进行血清HBs Ag检测,观察其阳性率。组间比较采用χ2检验。结果高考组的HBs Ag携带率分别为4.2%(75/1794)、4.3%(77/1797)、4.4%(82/1858)、4.3%(82/1903)、3.4%(56/1627)、2.6%(46/1768)、1.6%(29/1778)、1.6%(27/1642)和1.8%(24/1367),平均3.2%(498/15534),显著低于成人组的平均7.1%(86/1208)(χ2=59.986,P<0.001)。高考组男性HBs Ag携带率(3.7%,266/7236)高于女性(2.8%,229/8298)(χ2=10.521,P=0.001);成人组男性HBs Ag携带率(8.8%,66/750)也显著高于女性(4.4%,20/458)(χ2=8.452,P=0.004)。成人组男性的HBs Ag携带率是高考组男性的2.4倍;成人组女性的HBs Ag携带率是高考组女性的1.6倍。结论 2006-2014年高考生的HBs Ag携带率持续下降,至2014年已超前达到2010年世界卫生组织西太平洋区域将<5岁人群HBs Ag携带率控制在2%以下的目标。Objective To investigate the HBs Ag seroprevalence in the young generation in Qidong of Jiangsu Province,China. Methods A total of 15 534 students for college entrance examination from 2006 to 2014 were randomly selected from three secondary schools in Qidong as student group. Some of them had hepatitis B vaccination at birth. A total of 1208 adults who had their routine checkups in our hospital from 2007 to 2013 were selected as adult group. It was confirmed that all of them did not have hepatitis B vaccination at birth. Serum HBs Ag levels of the two groups were measured using enzyme- linked immunosorbent assay and the seroprevalence was analyzed. Comparison of data between the two groups was made by chi- square test. Results In the 9 years from 2007 to 2013,the seroprevalence rates of HBs Ag in the student group were 4. 2%（ 75 /1794）,4. 3%（ 77 /1797）,4. 4%（ 82 /1858）,4. 3%（ 82 /1903）,3. 4%（ 56 /1627）,2. 6%（ 46 /1768）,1. 6%（ 29 /1778）,1. 6%（ 27 /1642）,and 1. 8%（ 24 /1367）,respectively. The mean HBs Ag seroprevalence of the student group was3. 2%（ 498 /15534）,significantly lower compared with 7. 1%（ 86 /1208） of the adult group（ χ2= 59. 986,P〈0. 001）. In both of the student group and the adult group,the males had a significantly higher HBs Ag seroprevalence than the females（ χ2= 10. 521,P = 0. 001;χ2= 8. 452,P = 0. 004） and the values were 3. 7%（ 266 /7236） vs 2. 8%（ 229 /8298） and 8. 8%（ 66 /750） vs 4. 4%（ 20 /458）,respectively. Among male subjects,the HBs Ag seroprevalence of the adult group was 2. 4 times that of the student group; among female subjects,the HBs Ag seroprevalence of the adult group was 1. 6 times that of the student group. Conclusion In the recent 9 years from 2006 to 2014,the HBs Ag seroprevalence in students for college entrance examination declined continuously. The goal set by the World Health Organization Western Pacific Region in 2010 had been achieved ahead of the schedule that the HBs Ag seroprevalence should be c

关 键 词：肝炎表面抗原 乙型 肝炎疫苗 乙型 青少年 

分 类 号：R512.62[医药卫生—内科学]