BDNF、TrkB在子宫内膜癌中的表达及意义  

Expressions and Significances of BDNF and Trk B in the Endometrial Carcinoma

作　　者：李莎[1] 王蓁[2] 袁芳[2] 张伟 李敏[1] 

机构地区：[1]青岛大学医学院,山东青岛266000 [2]青岛大学附属医院东区妇科,山东青岛266000 [3]青岛市妇女儿童医院,山东青岛266000

出　　处：《现代生物医学进展》2015年第30期5917-5920,共4页Progress in Modern Biomedicine

摘　　要：目的:观察脑源性神经生长因子(BDNF)及其受体酪氨酸激酶受体B(TrkB)在子宫内膜癌中的表达,并分析其临床意义。方法:采用免疫组织化学染色方法对11例正常子宫内膜、16例增生子宫内膜、31例子宫内膜癌组织进行BDNF及其受体TrkB表达的检测,并分析子宫内膜癌组织中BDNF、TrkB的表达与其临床病理特征的关系。结果:BDNF及TrkB在正常子宫内膜中呈阴性或弱阳性表达,在增生子宫内膜及子宫内膜癌中呈阳性表达,三组间的差异存在统计学意义(P<0.05)。子宫内膜癌中BDNF、TrkB的表达与肿瘤细胞分化程度、临床病理分期、肌层浸润深度、淋巴结转移的有无均显著相关(P<0.05)。结论:BDNF及其受体TrkB的相互作用可能在子宫内膜癌的发生发展中起重要作用,二者联合检测可能对子宫内膜癌的术前病情评估及术后预后预测均具有重要的参考意义。Objective： To observe the expressions of brain-derived neurotrophic factor（BDNF） and tyrosine kinase receptor B（Trk B） in endometrial carcinoma, and analyze their clinical significances. Methods： The expression of BDNF and TrkB was tested in 11 cases of normal endometrium, 16 cases of hyperplasia endometrium and 31 cases of endometrial carcinoma by using immunohistochemistry, and their relationship with the clinicopathological characteristics of endometrial carcinoma were analyzed.Results： BDNF and TrkB were negatively or weakly positively expressed in the normal endometrium, while they were positively expressed in the hyperplasia endometrium and endometrial carcinoma, statistically significant differences were found between the three groups（P〈0.05）. The expression of BDNF and TrkB in endometrial carcinoma were significantly correlated with the tumor cell differentiation, clinicopathologic staging, myometrial invasion and lymph node metastasis of endometrial carcinoma（P〈0.05）.Conclusions： The interaction of BDNF with TrkB may play an important role in the occurence and development of endometrial carcinoma, so the combined detection of them may have important referent meanings for the preoperative condition assessment and prognostic prediction of endometrial carcinoma.

关 键 词：脑源性神经生长因子 酪氨酸激酶受体B 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]