122例男性不育患者染色体核型分析  

Analysis of chromosome karyotypeamong 122 infertile males patients

作　　者：周伟[1] 李新伟[1] 张群芝[1] 

机构地区：[1]漯河医学高等专科学校生物教研室,河南漯河462002

出　　处：《中国性科学》2015年第10期82-85,共4页Chinese Journal of Human Sexuality

基　　金：河南省科技厅年度计划项目(132300410471)

摘　　要：目的:对男性不育患者进行染色体核型的检测,探讨男性不育与染色体核型异常的关系。方法:按常规方法制作染色体标本的方法,对122例男性不育患者进行核型分析。结果:共检出染色体异常17例,异常率为13.93%。其中性染色体异常12例,占男性不育患者的9.84%,常染色体异常5例,占男性不育患者的4.10%。在所有的核型中,Klinefelter综合征的发生率最高,占异常核型的23.53%。结论:染色体异常是导致男性不育的重要原因之一,染色体核型分析对男性不育患者的诊断和治疗具有重要的指导意义。Objectives： To analyze the karyotypes of infertile male patients so as to investigate the relationship between male infertility and chromosome abnormalities. Methods： The chromosome karyotypes of 122 male infertile patients were analyzed by routinely cultured peripheral blood lymphocytes. Results： There were 17 cases of abnormal karyotypes which accounted for 13. 93%,including 12（ 9. 84%） cases of sex abnormal karyotype and 5（ 4. 10%） cases of autosome abnormal karyotype. The klinefelter syndrome was the most common disease caused by abnormal karyotype and the ratio was 23. 53% in all the abnormal karyotypes. Conclusion： Chromosome abnormality is an important cause of male infertility. Karyotype analysis is important for the diagnosis and treatment of male infertility.

关 键 词：男性不育 染色体异常 核型分析 

分 类 号：R596[医药卫生—内科学]