维药神香草提取物对Ⅰ型糖尿病小鼠血糖及糖耐量的影响  

Effects of Hyssopus cuspidatus Boriss on blood glucose and glucose tolerance in type 1 diabetes mice

作　　者：郭玉婷[1] 耿直[2] 兰卫[2] 田思敏[3] 刘天志 唐明敏[3] 赵保胜[3] 

机构地区：[1]新疆医科大学对口协作办公室 [2]新疆名医名方与特色方剂学自治区重点实验室,乌鲁木齐830011 [3]北京中医药大学科研实验中心,北京100029 [4]新疆和田阳光沙漠玫瑰有限公司,新疆和田834000

出　　处：《新疆医科大学学报》2015年第11期1351-1353,共3页Journal of Xinjiang Medical University

基　　金：国家自然科学基金(81374027);新疆维吾尔自治区科技支撑项目(201331109)

摘　　要：目的观察维药神香草提取物对糖尿病小鼠血糖及糖耐量的影响。方法腹腔注射四氧嘧啶法建立小鼠Ⅰ型糖尿病模型,模型成功的小鼠随机分为模型组、SXC大剂量组(200mg/kg)、SXC中剂量组(100mg/kg)、SXC小剂量组(50mg/kg)和阿卡波糖(113mg/kg)组,每组10只。另选10只未注射STZ的正常ICR小鼠为正常对照组,各组小鼠给予不同的药物或蒸馏水处理,共计7d,血糖试纸法测定血糖,观察神香草提取物对糖尿病小鼠血糖的影响,同时进行葡萄糖耐量试验(OGTT),观察香草提取物对糖尿病小鼠糖耐量的改善作用。结果神香草提取物可明显增加糖尿病小鼠的体质量(P<0.05或P<0.01),降低Ⅰ型糖尿病小鼠的血糖,并明显改善其糖耐量,三者均显示出一定的量-效关系。结论神香草提取物具有较好的降血糖和改善异常糖耐量的作用,可用于临床治疗糖尿病。Objective To observe the influence of Hyssopus cuspidatus Boriss（HCB）against hyperglycemia and sugar tolerance impairment.Methods Alloxan was intraperitoneal injected to the mice to establish type 1diabetes animal model,the type 1diabetes mice were randomly divided into 5groups,namely,they were model group,SXC high（200mg/kg）,middle（100mg/kg）,low groups（50mg/kg）and acarbose group（113mg/kg）,while 10 normal ICR mice were made as control group.Each group was respectively administrated the corresponding component or distilled water（for control and model group）for 7days.Blood glucose and oral glucose tolerance test（OGTT）were measured.Results Different doses of HCB increased the bodyweight,decreased the blood glucose,and improved the sugar tolerance of type 1diabetes mice obviously in dose-dependent way.Conclusion Hyssopus cuspidatus Boriss have certain antihyperglycemia and improve sugar tolerance impairment,hence may deal with diabetes in clinical.

关 键 词：神香草 Ⅰ型糖尿病 葡萄糖耐量实验 

分 类 号：R914[医药卫生—药物化学]