维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复的疗效观察  

Clinical effect of vitamin A palmitate eye gel on early ocular surface reconstruction after thermal or chemical injuries

作　　者：张分队[1] 王晶晶[2] 高伟[1] 朱海峰[1] 龙潭[1] 吴洁[1] 

机构地区：[1]中国陕西省西安市第一医院眼科,710002 [2]第四军医大学西京医院眼科,中国陕西省西安市710032

出　　处：《国际眼科杂志》2015年第11期1949-1952,共4页International Eye Science

摘　　要：目的:观察维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复的临床疗效。方法:采用随机、双盲、阳性药物平行对照方法,将78例眼烧伤患者随机分为维生素A棕榈酸酯眼用凝胶治疗组(A组,40例),碱性成纤维细胞生长因子(b FGF)滴眼液治疗组(B组,38例)。维生素A棕榈酸酯眼用凝胶和b FGF滴眼液均点眼4次/d,疗程为14d,观察两组的角膜上皮修复情况、干眼检查结果、症状及体征评分等指标。结果:维生素A棕榈酸酯眼用凝胶治疗组痊愈31例,显效5例,痊愈率为76%,有效率90%;b FGF治疗组痊愈32例,显效3例,痊愈率为84%,有效率为92%,两组之间无统计学差异(P>0.05),但维生素A棕榈酸酯眼用凝胶治疗组的Schirmer实验结果、泪膜破裂时间(BUT)与b FGF治疗组相比,均延长,两组之间有统计学差异(P<0.05);而且维生素A棕榈酸酯眼用凝胶治疗组患者的眼干、涩以及异物感的症状减轻程度明显好于b FGF治疗组,两者之间有统计学差异(P<0.05)。结论:维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复疗效确切、应用方便。AIM：To evaluate the clinical effect of vitamin A palmitate eye gel on early ocular surface reconstruction after thermal or chemical injuries.METHODS：Seventy- eight cases with thermal or chemical injuries to eyes were selected and divided into two groups by randomized,double-blind,positive drug parallel controlled method：group A（40 cases were treated with vitamin A palmitate eye gel） and group B[38 cases were treated with basic fibroblast growth factor（bFGF）].The bFGF and vitamin A palmitate eye gel were used 4 times a day.The treatment course was 14 d.Restoration of epithelial defect,Schirmer＇s test values,tear break-up time（BUT）,and subjective assessment of symptoms and signs were observed on D1,D3,D5,D7,D10 and D14.RESULTS：In group A,31 cases were cured,5 cases were effective,with the cure rate of 76%and efficiency90%.In group B,32 cases were cured,3 cases were effective,with the cure rate of 84%and efficiency 92%.There were no significant differences between the two groups（P〈0.05）.However,there were significant differences on the results of Schirmer＇s test and BUT（P〈0.05）,those in group A were expanded compared with group B.Symptoms of dry eye,astringent and foreign body sensation of group A were significantly better than those of group B,there were significant differences（P〈0.05）.CONCLUSION：Vitamin A palmitate eye gel is valuable and safe on early ocular surface reconstruction of the eyes suffered from thermal or chemical injuries.

关 键 词：维生素A棕榈酸酯眼用凝胶 眼烧伤 眼表修复 

分 类 号：R779.1[医药卫生—眼科]