71例Ⅲ-N2期非小细胞肺癌综合治疗病例的生存分析  

Survival Analysis of Ⅲ-N2 Non-Small-Cell Lung Cancer in 71 Patients

作　　者：陆莎[1] 祖超[2] 冯征[2] 王艳[2] 卢强[2] 陈召[2] 张天翼[2] 李小飞[2] 

机构地区：[1]西安市中心医院重症医学科,陕西西安710038 [2]第四军医大学唐都医院胸腔外科,陕西西安710038

出　　处：《现代生物医学进展》2015年第29期5678-5681,5654,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81172224)

摘　　要：目的:对71例Ⅲ-N2期非小细胞肺癌综合治疗的病例进行生存分析。方法:我院2007年3月至2014年3月诊断为Ⅲ-N2期的非小细胞肺癌患者71例,所有患者均接受手术、诱导或辅助化疗及术后放疗。采用Kaplan-Meier法对以上患者的总生存期(overall survival,OS)和无病生存期(disease free survival,DFS)进行分析。结果:71例患者的中位生存期为32个月,1年、3年和5年生存率分别为84.5%、49.6%和35.5%;1年、3年和5年无病生存率分别为70.4%、41.8%和27.4%;9例患者(12.6%)出现局部复发;鳞状细胞癌患者的中位生存期为43个月,而腺癌患者的中位生存期为21个月。鳞癌患者1年、3年、5年的OS和DFS分别为85%、60%、42.5%和80.0%、55.0%、34.2%;腺癌患者1年、3年、5年的OS和DFS分别为77.1%、42.0%、36.0%和60.0%、28.6%、28.6%,两组OS和DFS均无显著性差异。Objective： To study the impact of trimodal therapy for stage Ⅲ-N2 NSCLC a single centre retrospective evaluation focusing on survival and therapy-related toxicity was performed. Methods： 71 patients diagnosed between March 2007 and August 2014 with pathologically confirmed stage Ⅲ-N2 non-small-cell lung cancer at the University Clinic of Heidelberg were retrospectively analyzed. All patients were treated within trimodal therapy strategies including surgery, induction or adjuvant chemotherapy and postoperative radiotherapy. Overall survival（OS） and disease free survival（DFS） rates were calculated using the Kaplan-Meier method. Results：Median survival was 32 months. 1-, 3- and 5-year overall survival（OS） rates were 84.5%, 49.6% and 35.5% respectively. Disease free survival rates at 1, 3 and 5 years were 70.4%, 41.8% and 27.4% respectively. 9 patients（12.6%） were diagnosed with a local recurrence.Multivariate analysis did not reveal any independent prognostic factors for OS, but indicated a trend for p T stage and type of surgery.Conclusions： Our descriptive data indicate that trimodal therapy represents an effective and safe treatment approach for patients with stage Ⅲ-N2 non-small-cell lung cancer. Differences survival was found in different kinds of NSCLC with comprehensive treatment.

关 键 词：非小细胞肺癌 综合疗法 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]