肝萎缩增生复合征及肝萎缩病理和代谢功能研究进展  

Progress on the Pathogenesis, Pathology and Physiological Functions of Liver Atrophy-hypertrophy Complex

作　　者：涂玉亮[1] 刘荣[2] 

机构地区：[1]解放军总医院第一附属医院肝胆胰脾外科,北京100048 [2]解放军总医院肿瘤外二科,北京100853

出　　处：《现代生物医学进展》2015年第29期5797-5800,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(81301239)

摘　　要：肝萎缩增生复合征(atrophy-hypertrophy complex,AHC)是指肝组织萎缩和代偿性增生的一种临床病理特征,常见的病因有门静脉流入受阻、肝静脉流出受阻、胆道梗阻等。AHC常伴有区域性肝组织的解剖、病理、代谢功能的改变,包括肝脏沿肝门轴的旋转、萎缩肝叶的纤维化和门管区小门静脉的狭窄或血栓形成等。肝萎缩-增生复合征萎缩肝组织仍具有部分代谢功能和生物转化功能,并可能对维持病变肝脏的正常肝功能具有重要的作用,萎缩肝组织仍具有部分代谢功能和生物转化功能,对萎缩肝组织的代谢分区和代谢功能的进一步研究具有重要意义。本文通过分析近年来国内外有关AHC的文献,探讨AHC的病因、病理变化及萎缩肝组织的代谢功能分化特征的研究进展。To review the recent years literatures of the pathogenesis, pathology and physiological functions of liver atrophy-hy- pertrophy complex （AHC） and to discuss the progress of them. Literatures ofNCBI PubMed and CBMdisc on research of the pathogenesis, pathology and physiological functions of AHC were reviewed. Liver AHC refers to a clinical pathological characteristics on the compen- satory hypertrophy of liver parenchyma following hepatocyte loss. AHC is caused by portal vein obstruction, biliary obstruction and hep- atic vein obstruction, with the lesions of regional anatomy, pathology and metabolic function, including hepatic rotation along the hilar axis, advanced septal fibrosis and stenosis or thrombosis of portal vein. There are some of functions of metabolism and biotransformation, however they are rare to be studied. Preservation of the atrophy hepatic tissue plays an important role in maintaining normal liver function in some lesions, and it is significant to further research the change of the metabolic zonafion and metabolic function of atrophic liver.

关 键 词：肝萎缩增生复合征 病因 病理 代谢功能 

分 类 号：R575.5[医药卫生—消化系统]