青岛汉族人群MIF基因启动子区-173G/C多态性与HBV感染易感性的关系  

RELATIONSHIP BETWEEN-173G/C POLYMORPHISM IN THE PROMOTER OF MIF AND HBV SUSCEPTIBILITY INFECTION IN HAN POPULATION OF QINGDAO

作　　者：任伟[1] 刘颂[1] 舒君[1] 王敬丽[2] 王祖森[3] 

机构地区：[1]青岛大学医学院微生物学教研室,山东青岛266021 [2]青岛大学附属医院产前诊断实验室,山东青岛266021 [3]青岛大学附属医院肝胆外科,山东青岛266021

出　　处：《青岛大学医学院学报》2015年第6期712-713,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨青岛汉族人群巨噬细胞移动抑制因子(MIF)基因启动子区-173G/C(MIF-173G/C)多态性与乙型肝炎病毒(HBV)感染易感性的关系。方法选取青岛汉族596例HBV感染病人和612例年龄匹配的对照者标本,采用等位基因特异性聚合酶链反应对MIF-173G/C多态性进行基因分型,比较两组等位基因及基因型频率的差异。结果两组间基因型分布比较差异无显著性(P>0.05);而HBV感染组C等位基因的频率明显高于对照组(χ2=4.59,P<0.05)。男性和女性两组间基因型和等位基因频率比较差异无显著性(P>0.05)。结论MIF-173G/C多态性与青岛汉族人群HBV感染有关,C等位基因可能是HBV感染的易感性标志,且这种易感性无性别差异。Objective To investigate the correlation between polymorphism in the MIF gene（173G/C）and HBV susceptibility infection in a Chinese Han population of Qingdao. Methods Samples of 596 patients with HBV infection and 612 agematched controls of Han people of Qingdao were selected.Genotyping of MIF-173G/C polymorphism was performed by using allele-specific polymerase chain reaction method.The frequencies of the alleles and genotypes between the two groups were compared.Results There was no significant difference in genotype distribution between the two groups（P〉0.05）,and in HBV-infection group,the frequency of C-allele was significantly higher than that in the control group（χ2=4.59,P〈0.05）.However,no obvious differences were found in men between the two groups,and in women between the two groups with regard to genotype MIF-173G/C and allele frequency（P〉0.05）. Conclusion MIF-173G/C polymorphism is associated with HBV infection in Han population of Qingdao area,the MIF-173 Callele is likely to be a marker of sensitivity of HBV infection,and this sensitivity.

关 键 词：巨噬细胞移动抑制因子 乙型病毒性肝炎 基因多态性 

分 类 号：R512.62[医药卫生—内科学]