Ⅲ期非小细胞肺癌合并继发型肺结核放疗时机的研究  

Selection of radiotherapy opportunity of stage Ⅲ non-small cell lung cancer complicated by secondary pulmonary tuberculosis

作　　者：梁香存[1] 王庆[1] 梁凯[2] 梁健[1] 才虹美[1] 张俊萍[1] 

机构地区：[1]河北省胸科医院肺肿瘤二科,石家庄市050041 [2]石家庄经济学院职工医院

出　　处：《河北医药》2015年第20期3048-3051,共4页Hebei Medical Journal

摘　　要：目的：探讨Ⅲ期非小细胞肺癌合并继发型肺结核的放疗时机。方法回顾分析2005年1月至2011年12月接受放疗的Ⅲ期非小细胞肺癌合并继发型肺结核患者78例。将其分为早放疗组（抗痨1～2周后开始放疗）和晚放疗组（抗痨1～2个月后开始放疗），早放疗组42例，晚放疗组36例。比较2组患者疗效及毒副反应的差异。结果早放疗组与晚放疗组疗效比较：结核吸收率分别为73忖．8％、88．9％，无变化率分别为26．2％、11．1％，恶化率均为0，2组比较差异无统计学意义（ P ＞0．05）；1、2、3年总生存率分别为66．7％、42．9％、19．0％及63．9％、16．7％、2．8％（χ2＝3．958， P ＝0．047）。结论Ⅲ期非小细胞肺癌合并继发型肺结核放疗时机选择在抗痨1～2周后开始较合理，没有导致结核播散，延长了患者的总生存。Objective To investigate the radiotherapy opportunity of stage Ⅲ non-small cell lung cancer （ NSCLC） complicated by secondary pulmonary tuberculosis.Methods The data of 78 patients with stage Ⅲ NSCLC complicated by secondary pulmonary tuberculosis who were hospitalized and received radiotherapy in Hebei Provincial Chest Hospital from January 2005 to December 2011 were retrospective analyzed.These patients were divided into early radiotherapy group （ n =42） who received radiotherapy after 1～2 week anti-tuberculosis treatment and late radiotherapy group （ n =36） who received radiotherapy after 1 ～2 month anti-tuberculosis treatment, The therapeutic effects and adverse reactions were observed and compared between two groups.Results The tuberculosis absorption rates in early radiotherapy group and late radiotherapy group were 73.8%and 88.9%,respectively, stability rates were 26.2% and 11.1%, respectively, and deterioration rates were 0%in both groups,there were no significant differences between two groups （ P 〉0.05）.The 1-year, 2-year, 3-year survival rates in early radiotherapy group and late radiotherapy group were 66.7%, 42.9%, 19.0% and 63.9%, 16.7%, 2.8%,respectively （χ2 =3.958, P 〈0.05）.Conclusion It is reasonable to begin the radiotherapy for stage Ⅲ non-small cell lung cancer complicated by secondary pulmonary tuberculosis after 1～2 week anti-tuberculosis treatment, which can prolong patient’ s total survival rates,without resulting in tuberculosis spreading.

关 键 词：Ⅲ期非小细胞肺癌 继发型肺结核 放疗时机 

分 类 号：R734.2[医药卫生—肿瘤]